Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress
المؤلفون المشاركون
Jahan, Nazish
Rahman, Khalil-ur-
Afsheen, Nadia
Ijaz, Misbah
Manzoor, Asad
Khan, Khalid Mahmood
Hina, Saman
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-14
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
In this research work, the antioxidant and metabolomic profiling of seven selected medicinally important herbs including Rauvolfia serpentina, Terminalia arjuna, Coriandrum sativum, Elettaria cardamom, Piper nigrum, Allium sativum, and Crataegus oxyacantha was performed.
The in vivo cardioprotective potential of these medicinal plants was evaluated against surgically induced oxidative stress through left anterior descending coronary artery ligation (LADCA) in dogs.
The antioxidant profiling of these plants was done through DPPH and DNA protection assay.
The C.
oxyacantha and T.
arjuna showed maximum antioxidant potential, while the E.
cardamom showed poor antioxidative strength even at its high concentration.
Different concentrations of extracts of the said plants exhibited the protection of plasmid DNA against H2O2 damage as compared to the plasmid DNA merely treated with H2O2.
The metabolomic profiling through LC-MS analysis of these antioxidants revealed the presence of active secondary metabolites responsible for their antioxidant potential.
During in vivo analysis, blood samples of all treatment groups were drawn at different time intervals to analyze the cardiac and hemodynamic parameters.
The results depicted that the group pretreated with HC4 significantly sustained the level of CK-MB, SGOT, and LDH as well as hemodynamic parameters near to normal.
The histopathological examination also confirmed the cardioprotective potential of HC4.
Thus, the HC4 being safe and inexpensive cardioprotective herbal combination could be considered as an alternate of synthetic drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Afsheen, Nadia& Rahman, Khalil-ur-& Jahan, Nazish& Ijaz, Misbah& Manzoor, Asad& Khan, Khalid Mahmood…[et al.]. 2018. Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1212409
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Afsheen, Nadia…[et al.]. Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1212409
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Afsheen, Nadia& Rahman, Khalil-ur-& Jahan, Nazish& Ijaz, Misbah& Manzoor, Asad& Khan, Khalid Mahmood…[et al.]. Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1212409
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212409
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر