Local Treatment of Metastatic Prostate Cancer: What is the Evidence So Far?
المؤلفون المشاركون
Leonel Almeida, Pedro
Jorge Pereira, Bruno
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Advances in technological, laboratorial, and imaging studies and new treatments available in the last decades significantly improved prostate cancer survival rates.
However, this did not occur in metastatic prostate cancer (mPCa) at diagnosis which, in young and fit patients, will become invariably resistant to the established treatments.
Progression will lead to an impairment in patients’ quality of life and disease-related death.
Methods.
The authors intend to perform a literature review of the advantages of primary treatment of mPCa.
Articles were retrieved and filtered for relevance from PubMed, SciELO, and ScienceDirect until March 2017.
Results.
Primary treatment is currently indicated only in cases of nonmetastatic PCa.
Nonetheless, there might be some benefits in doing local treatment in mPCa in order to control local disease, prevent new metastasis, and improve the efficacy of chemotherapy and hormonotherapy with similar complications rate when compared to locally confined cancer.
Independent factors that have a negative influence are age above 70 years, cT4 stage or high-grade disease, PSA≥20 ng/ml, and pelvic lymphadenopathies.
The presence of 3 or more of these factors conditions CSS and OS is the same between patients who performed local treatment and those who did not.
Metastasis degree and location number can also influence outcome.
Meanwhile, patients with visceral metastases have worse results.
Conclusions.
There is growing evidence supporting local treatment in cases of metastatic prostate cancer at diagnosis in the context of a multimodal approach.
However, it should be kept in mind that most of the existing studies are retrospective and it would be important to make consistent prospective studies with well-defined patient selection criteria in order to sustain the existing data and understand the main indications to select patients and perform primary treatment in mPCa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leonel Almeida, Pedro& Jorge Pereira, Bruno. 2018. Local Treatment of Metastatic Prostate Cancer: What is the Evidence So Far?. Prostate Cancer،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leonel Almeida, Pedro& Jorge Pereira, Bruno. Local Treatment of Metastatic Prostate Cancer: What is the Evidence So Far?. Prostate Cancer No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leonel Almeida, Pedro& Jorge Pereira, Bruno. Local Treatment of Metastatic Prostate Cancer: What is the Evidence So Far?. Prostate Cancer. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر