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Microarray Analysis of the Molecular Mechanism Involved in Parkinson’s Disease
المؤلفون المشاركون
Tan, Cheng
Liu, Xiaoyang
Chen, Jiajun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
This study aimed to investigate the underlying molecular mechanisms of Parkinson’s disease (PD) by bioinformatics.
Methods.
Using the microarray dataset GSE72267 from the Gene Expression Omnibus database, which included 40 blood samples from PD patients and 19 matched controls, differentially expressed genes (DEGs) were identified after data preprocessing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses.
Protein-protein interaction (PPI) network, microRNA- (miRNA-) target regulatory network, and transcription factor- (TF-) target regulatory networks were constructed.
Results.
Of 819 DEGs obtained, 359 were upregulated and 460 were downregulated.
Two GO terms, “rRNA processing” and “cytoplasm,” and two KEGG pathways, “metabolic pathways” and “TNF signaling pathway,” played roles in PD development.
Intercellular adhesion molecule 1 (ICAM1) was the hub node in the PPI network; hsa-miR-7-5p, hsa-miR-433-3p, and hsa-miR-133b participated in PD pathogenesis.
Six TFs, including zinc finger and BTB domain-containing 7A, ovo-like transcriptional repressor 1, GATA-binding protein 3, transcription factor dp-1, SMAD family member 1, and quiescin sulfhydryl oxidase 1, were related to PD.
Conclusions.
“rRNA processing,” “cytoplasm,” “metabolic pathways,” and “TNF signaling pathway” were key pathways involved in PD.
ICAM1, hsa-miR-7-5p, hsa-miR-433-3p, hsa-miR-133b, and the abovementioned six TFs might play important roles in PD development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tan, Cheng& Liu, Xiaoyang& Chen, Jiajun. 2018. Microarray Analysis of the Molecular Mechanism Involved in Parkinson’s Disease. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212446
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tan, Cheng…[et al.]. Microarray Analysis of the Molecular Mechanism Involved in Parkinson’s Disease. Parkinson’s Disease No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212446
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tan, Cheng& Liu, Xiaoyang& Chen, Jiajun. Microarray Analysis of the Molecular Mechanism Involved in Parkinson’s Disease. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212446
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212446
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