Potential Therapeutic Drugs for Parkinson’s Disease Based on Data Mining and Bioinformatics Analysis
المؤلفون المشاركون
Chen, Jiajun
Xu, Chuan
Xu, Xia
Zhang, Yingyu
Li, Jia
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The objective is to search potential therapeutic drugs for Parkinson’s disease based on data mining and bioinformatics analysis and providing new ideas for research studies on “new application of conventional drugs.” Method differential gene candidates were obtained based on data mining of genes of PD brain tissue, original gene data analysis, differential gene crossover, pathway enrichment analysis, and protein interaction, and potential therapeutic drugs for Parkinson’s disease were obtained through drug-gene relationship.
Result.
250 common differential genes were obtained from 3 research studies, and 31 differential gene candidates were obtained through gene enrichment analysis and protein interaction.
10 drugs such as metformin hydrochloride were directly or indirectly correlated to differential gene candidates.
Conclusion.
Potential therapeutic drugs that may be used for prevention and treatment of Parkinson’s disease were discovered through data mining and bioinformatics analysis, which provided new ideas for research and development of drugs.
Results showed that metformin hydrochloride and other drugs had certain therapeutical effect on Parkinson’s disease, and melbine (DMBG) can be used for treatment of Parkinson’s disease and type 2 diabetes patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Chuan& Chen, Jiajun& Xu, Xia& Zhang, Yingyu& Li, Jia. 2018. Potential Therapeutic Drugs for Parkinson’s Disease Based on Data Mining and Bioinformatics Analysis. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212458
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Chuan…[et al.]. Potential Therapeutic Drugs for Parkinson’s Disease Based on Data Mining and Bioinformatics Analysis. Parkinson’s Disease No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1212458
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Chuan& Chen, Jiajun& Xu, Xia& Zhang, Yingyu& Li, Jia. Potential Therapeutic Drugs for Parkinson’s Disease Based on Data Mining and Bioinformatics Analysis. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212458
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212458
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر