Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson’s Disease: A Cross-Sectional Study
المؤلفون المشاركون
Smania, Nicola
Gandolfi, Marialuisa
Waldner, Andreas
Dassati, Sarah
Redl, Bernhard
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an important role in several neurodegenerative diseases.
ApoD is expressed in and secreted from a variety of peripheral and brain tissues.
Increments of ApoD have been reported in relation with oxidative stress conditions, aging, and degeneration in the nervous system.
Preliminary findings support the role of ApoD in neuroprotection.
However, its role in PD remains unclear.
To date, no studies have been performed on the relationship between ApoD in the blood and PD, as neurodegenerative pathology related to oxidative damage.
We investigated the concentration of ApoD in the blood of healthy control subjects and PD patients with mild-to-moderate neurological impairment.
ApoD plasma levels were measured using sandwich enzyme-linked immunosorbent assays (ELISA) in 90 healthy subjects (aging-analysis cohort) and in 66 PD patients at different stages compared with 19 age-matched healthy subjects.
Significant age-related increase of ApoD was detected in subjects older than 65 years of age (p<0.002).
In PD patients, a significant increase in ApoD plasma concentration was found compared with healthy subjects of the same age (p<0.05).
ApoD and PD stage are significantly correlated (p<0.05).
ApoD might be a valid marker for the progression of PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Waldner, Andreas& Dassati, Sarah& Redl, Bernhard& Smania, Nicola& Gandolfi, Marialuisa. 2018. Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson’s Disease: A Cross-Sectional Study. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212460
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Waldner, Andreas…[et al.]. Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson’s Disease: A Cross-Sectional Study. Parkinson’s Disease No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212460
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Waldner, Andreas& Dassati, Sarah& Redl, Bernhard& Smania, Nicola& Gandolfi, Marialuisa. Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson’s Disease: A Cross-Sectional Study. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212460
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212460
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر