CLOCK 3111TC Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease
المؤلفون المشاركون
Luo, Xiaoguang
Lou, Fan
Li, Ming
Ren, Yan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The clock genes controlling biological rhythm play an important role in the pathophysiology of aging.
The purpose of this study was to determine whether there is an association between a variant of the circadian locomotor output cycles kaput (CLOCK) gene and circadian dysfunction of Parkinson’s disease (PD).
Methods.
Six hundred and forty-six cases of Parkinson’s disease from consecutive outpatients and inpatients ward from our hospital were included in this study.
Kompetitive allele-specific PCR was used to determine the frequency distribution of genotypes and alleles.
The examinations for the PD group were assessed in person in order to evaluate motor symptoms, cognitive function, sleep, and depression, including the Unified Parkinson’s Disease Rating Scale (UPDRS), Mini-Mental State Examination (MMSE), Pittsburgh Sleep Quality Index (PSQI), and 17-item Hamilton Rating Scale for Depression (HAMD-17).
Results.
Motor fluctuation (P<0.001) and sleep disorders (P=0.007) were significantly different between the two groups.
These correlations persisted after adjusting for confounding risk factors by further binary logistic regression analysis, suggesting that the CLOCK 3111T/C variant was associated with motor fluctuation (OR = 1.080, P<0.001) and a subjective sleep disorder (OR = 1.130, P=0.037).
Conclusion.
The CLOCK 3111T/C variant can be an independent risk factor for motor fluctuation and sleep disorder in Parkinson’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lou, Fan& Li, Ming& Luo, Xiaoguang& Ren, Yan. 2018. CLOCK 3111TC Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212468
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lou, Fan…[et al.]. CLOCK 3111TC Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease. Parkinson’s Disease No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1212468
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lou, Fan& Li, Ming& Luo, Xiaoguang& Ren, Yan. CLOCK 3111TC Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212468
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212468
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر