Pisa Syndrome in Parkinson’s Disease: Evidence for Bilateral Vestibulospinal Dysfunction
المؤلفون المشاركون
Di Mauro, Roberta
Schirinzi, Tommaso
Di Lazzaro, Giulia
Palmieri, M. G.
Di Girolamo, Stefano
Tinazzi, Michele
Giambrone, Maria Pia
Rocchi, Camilla
Mercuri, Nicola Biagio
Pisani, Antonio
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Pisa syndrome (PS) is a postural complication of Parkinson’s disease (PD).
Yet, its pathophysiology remains unclear, although a multifactorial component is probable.
Cervical vestibular evoked myogenic potentials (cVEMPs) explore vestibulospinal pathway, but they have not been measured yet in PD patients with PS (PDPS) to assess a potential vestibular impairment.
Materials and Methods.
We enrolled 15 PD patients, 15 PDPS patients, and 30 healthy controls (HCs).
They underwent neurological examination and were examined with Unified Parkinson’s Disease Rating Scale II-III (UPDRSII-III), audiovestibular workup, and cVEMP recordings.
Data were analysed with Chi-square, one-way ANOVA, multinomial regression, nonparametric, and Spearman’s tests.
Results.
cVEMPs were significantly impaired in both PD and PDPS compared with HCs.
PDPS exhibited more severe cVEMP abnormalities with prevalent bilateral loss of potentials, compared with the PD group, in which a prevalent unilateral loss was instead observed.
No clinical-neurophysiological correlations emerged.
Conclusions.
Differently from HC, cVEMPs are altered in PD.
Severity of cVEMPs alterations increases from PD without PS to PDPS, suggesting an involvement of vestibulospinal pathway in the pathophysiology of PS.
Our results provide evidence for a significant impairment of cVEMPs in PDPS patients and encourage further studies to test validity of cVEMPs as diagnostic and prognostic biomarkers of PD progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Di Lazzaro, Giulia& Schirinzi, Tommaso& Giambrone, Maria Pia& Di Mauro, Roberta& Palmieri, M. G.& Rocchi, Camilla…[et al.]. 2018. Pisa Syndrome in Parkinson’s Disease: Evidence for Bilateral Vestibulospinal Dysfunction. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Di Lazzaro, Giulia…[et al.]. Pisa Syndrome in Parkinson’s Disease: Evidence for Bilateral Vestibulospinal Dysfunction. Parkinson’s Disease No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1212489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Di Lazzaro, Giulia& Schirinzi, Tommaso& Giambrone, Maria Pia& Di Mauro, Roberta& Palmieri, M. G.& Rocchi, Camilla…[et al.]. Pisa Syndrome in Parkinson’s Disease: Evidence for Bilateral Vestibulospinal Dysfunction. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر