Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor

المؤلفون المشاركون

Park, Joo-In
Yun, Seong-Hoon
Han, Sang-Heum

المصدر

PPAR Research

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-01-21

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الأحياء

الملخص EN

Peroxisome proliferator-activated receptor γ (PPARγ) is part of a nuclear receptor superfamily that regulates gene expression involved in cell differentiation, proliferation, immune/inflammation response, and lipid metabolism.

PPARγ coactivator-1α (PGC-1α), initially identified as a PPARγ-interacting protein, is an important regulator of diverse metabolic pathways, such as oxidative metabolism and energy homeostasis.

The role of PGC-1α in diabetes, neurodegeneration, and cardiovascular disease is particularly well known.

PGC-1α is also now known to play important roles in cancer, independent of the role of PPARγ in cancer.

Though many researchers have studied the expression and clinical implications of PPARγ and PGC-1α in cancer, there are still many controversies about the role of PPARγ and PGC-1α in cancer.

This review examines and summarizes some recent data on the role and action mechanisms of PPARγ and PGC-1α in cancer, respectively, particularly the recent progress in understanding the role of PPARγ in several cancers since our review was published in 2012.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yun, Seong-Hoon& Han, Sang-Heum& Park, Joo-In. 2018. Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor. PPAR Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212524

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yun, Seong-Hoon…[et al.]. Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor. PPAR Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212524

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yun, Seong-Hoon& Han, Sang-Heum& Park, Joo-In. Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212524

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1212524