Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor
Joint Authors
Park, Joo-In
Yun, Seong-Hoon
Han, Sang-Heum
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor γ (PPARγ) is part of a nuclear receptor superfamily that regulates gene expression involved in cell differentiation, proliferation, immune/inflammation response, and lipid metabolism.
PPARγ coactivator-1α (PGC-1α), initially identified as a PPARγ-interacting protein, is an important regulator of diverse metabolic pathways, such as oxidative metabolism and energy homeostasis.
The role of PGC-1α in diabetes, neurodegeneration, and cardiovascular disease is particularly well known.
PGC-1α is also now known to play important roles in cancer, independent of the role of PPARγ in cancer.
Though many researchers have studied the expression and clinical implications of PPARγ and PGC-1α in cancer, there are still many controversies about the role of PPARγ and PGC-1α in cancer.
This review examines and summarizes some recent data on the role and action mechanisms of PPARγ and PGC-1α in cancer, respectively, particularly the recent progress in understanding the role of PPARγ in several cancers since our review was published in 2012.
American Psychological Association (APA)
Yun, Seong-Hoon& Han, Sang-Heum& Park, Joo-In. 2018. Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor. PPAR Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212524
Modern Language Association (MLA)
Yun, Seong-Hoon…[et al.]. Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor. PPAR Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212524
American Medical Association (AMA)
Yun, Seong-Hoon& Han, Sang-Heum& Park, Joo-In. Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212524