Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance

المؤلفون المشاركون

Huo, Yajing
Wu, Xuqing
Ding, Jing
Geng, Yang
Qiao, Weiwei
Ge, Anyan
Guo, Cen
Lv, Jianing
Bao, Haifeng
Fan, Wei

المصدر

PPAR Research

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-01-15

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأحياء

الملخص EN

Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome.

Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling.

We also studied oxidative stress and expression of PPARγ in the coronary arteriole as a possible mechanism underlying vascular remodeling.

Rats were treated with standard rodent chow (Control) or diet enriched in methionine (Met) for 48 weeks.

Plasma homocysteine, blood glucose, serum lipids, malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) levels were measured.

Coronary arteriolar and carotid arterial remodeling was assessed by histomorphometric techniques and the expression of PPARγ in vessel wall was investigated.

In Met group, an increase in the level of fasting blood glucose, serum triglyceride, total cholesterol, MDA, and NO, a decline in the serum SOD level, and increased collagen deposition in coronary and carotid arteries were found.

Moreover, we detected decreased expression of PPARγ in the coronary arterioles in Met group.

In summary, our study revealed metabolic disturbances in this model of long-term hyperhomocysteinemia together with vascular remodeling and suggested that impaired oxidative stress, endothelium dysfunction, and decreased PPARγ expression in the vessel wall could be underlying mechanisms.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Huo, Yajing& Wu, Xuqing& Ding, Jing& Geng, Yang& Qiao, Weiwei& Ge, Anyan…[et al.]. 2018. Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance. PPAR Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212525

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Huo, Yajing…[et al.]. Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance. PPAR Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212525

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Huo, Yajing& Wu, Xuqing& Ding, Jing& Geng, Yang& Qiao, Weiwei& Ge, Anyan…[et al.]. Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212525

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1212525