Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance
Joint Authors
Huo, Yajing
Wu, Xuqing
Ding, Jing
Geng, Yang
Qiao, Weiwei
Ge, Anyan
Guo, Cen
Lv, Jianing
Bao, Haifeng
Fan, Wei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome.
Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling.
We also studied oxidative stress and expression of PPARγ in the coronary arteriole as a possible mechanism underlying vascular remodeling.
Rats were treated with standard rodent chow (Control) or diet enriched in methionine (Met) for 48 weeks.
Plasma homocysteine, blood glucose, serum lipids, malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) levels were measured.
Coronary arteriolar and carotid arterial remodeling was assessed by histomorphometric techniques and the expression of PPARγ in vessel wall was investigated.
In Met group, an increase in the level of fasting blood glucose, serum triglyceride, total cholesterol, MDA, and NO, a decline in the serum SOD level, and increased collagen deposition in coronary and carotid arteries were found.
Moreover, we detected decreased expression of PPARγ in the coronary arterioles in Met group.
In summary, our study revealed metabolic disturbances in this model of long-term hyperhomocysteinemia together with vascular remodeling and suggested that impaired oxidative stress, endothelium dysfunction, and decreased PPARγ expression in the vessel wall could be underlying mechanisms.
American Psychological Association (APA)
Huo, Yajing& Wu, Xuqing& Ding, Jing& Geng, Yang& Qiao, Weiwei& Ge, Anyan…[et al.]. 2018. Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance. PPAR Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212525
Modern Language Association (MLA)
Huo, Yajing…[et al.]. Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance. PPAR Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212525
American Medical Association (AMA)
Huo, Yajing& Wu, Xuqing& Ding, Jing& Geng, Yang& Qiao, Weiwei& Ge, Anyan…[et al.]. Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212525