Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression

المؤلفون المشاركون

Park, Young Joo
Ahn, Hwa Young
Kim, Hwan Hee
Hwang, Ji-Yeon
Park, Changhun
Cho, Bo Youn

المصدر

PPAR Research

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-09-27

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأحياء

الملخص EN

Nonalcoholic fatty liver disease or steatohepatitis (NAFLD/NASH) is a fatty liver disease that is closely related to obesity, diabetes, and dyslipidemia.

Pioglitazone, which was developed as an antidiabetic drug, is known to improve NALFD.

Pioglitazone is metabolized by multiple cytochrome P450 (CYP) enzymes, which are regulated by the xenobiotic receptor constitutive androstane receptor (CAR).

In this study, we investigated the effects of pioglitazone on NAFLD by absence of CAR activity under high-fat (HF)-fed conditions.

CAR-/- mice showed significant improvement in NALFD after 12 weeks of pioglitazone treatment compared to wild-type mice.

This improvement in NAFLD persisted in CAR-/- mice regardless of blood pioglitazone concentration.

The expression of lipogenesis genes in the liver, sterol-regulatory element binding protein-1c (SREBP-1c), and stearoyl-CoA desaturase (SCD)-1 was decreased after pioglitazone treatment in HF-fed CAR-/- mice.

In addition, the expression of peroxisome proliferator-activated receptor gamma 2 (PPARγ2) was decreased by pioglitazone in HF-fed CAR-/- mice.

Changes in SREBP-1c and PPAR γ2 remained constant over short-term (6 h) pioglitazone and lipid injection.

Our results showed that NAFLD was improved significantly by pioglitazone in a CAR deletion state.

These results might be valuable because they suggest that interaction with CAR and pioglitazone/PPARγ2 may be important in regulating gene expression associated with NAFLD.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ahn, Hwa Young& Kim, Hwan Hee& Hwang, Ji-Yeon& Park, Changhun& Cho, Bo Youn& Park, Young Joo. 2018. Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression. PPAR Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212530

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ahn, Hwa Young…[et al.]. Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression. PPAR Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212530

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ahn, Hwa Young& Kim, Hwan Hee& Hwang, Ji-Yeon& Park, Changhun& Cho, Bo Youn& Park, Young Joo. Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212530

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1212530