Chemical Composition and Antioxidant, Analgesic, and Anti-Inflammatory Effects of Methanolic Extract of Euphorbia retusa in Mice
المؤلفون المشاركون
Rjeibi, Ilhem
Ncib, Sana
Hfaiedh, Najla
Sdayria, Jazia
Feriani, Anouar
Bouguerra, Wided
Elfeki, Abdelfattah
Allagui, Mohamed Salah
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Plants provide an alternative source to manage different human disorders due to various metabolites.
The aim of this study is to investigate the phytochemical constituents of the methanolic extracts of Euphorbia retusa and to evaluate their antioxidant, anti-inflammatory, and analgesic activities.
The phytochemical results obtained by HPLC and by chemical assay reactions have revealed the richness of the methanolic extract of E.
retusa in active compounds, in particular polyphenols, flavonoids, and tannins.
The methanolic extract shows significant antioxidant activities in vitro, in the DPPH and the FRAP assays.
The antinociceptive activity was evaluated using acetic acid and hot-plate models of pain in mice.
The anti-inflammatory activity was evaluated by carrageenan-induced paw edema.
Oral pretreatment with the methanolic extract of E.
retusa (200 mg/kg) exhibited a significant inhibition of pain induced either by acetic acid or by the heating plate and in a manner comparable to the standard drug paracetamol.
E.
retusa significantly reduced paw edema starting from the 3rd hour after carrageenan administration by increasing the activity of antioxidant enzymes (SOD, CAT, and GPx) in liver and paw tissues and decreasing the levels of MDA.
These results may confirm the interesting potential of this plant as a treatment of various inflammatory and pain diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sdayria, Jazia& Rjeibi, Ilhem& Feriani, Anouar& Ncib, Sana& Bouguerra, Wided& Hfaiedh, Najla…[et al.]. 2018. Chemical Composition and Antioxidant, Analgesic, and Anti-Inflammatory Effects of Methanolic Extract of Euphorbia retusa in Mice. Pain Research and Management،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212569
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sdayria, Jazia…[et al.]. Chemical Composition and Antioxidant, Analgesic, and Anti-Inflammatory Effects of Methanolic Extract of Euphorbia retusa in Mice. Pain Research and Management No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1212569
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sdayria, Jazia& Rjeibi, Ilhem& Feriani, Anouar& Ncib, Sana& Bouguerra, Wided& Hfaiedh, Najla…[et al.]. Chemical Composition and Antioxidant, Analgesic, and Anti-Inflammatory Effects of Methanolic Extract of Euphorbia retusa in Mice. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212569
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212569
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر