Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy
المؤلفون المشاركون
Griffiths, Lisa A.
Duggett, Natalie A.
Pitcher, Ann L.
Flatters, Sarah J. L.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Paclitaxel-induced neuropathic pain is a major dose-limiting side effect of paclitaxel therapy.
This study characterises a variety of rat behavioural responses induced by intermittent administration of clinically formulated paclitaxel.
2 mg/kg paclitaxel or equivalent vehicle was administered intraperitoneally on days 0, 2, 4, and 6 to adult male Sprague-Dawley rats.
Evoked pain-like behaviours were assessed with von Frey filaments, acetone, or radiant heat application to plantar hind paws to ascertain mechanical, cold, or heat sensitivity, respectively.
Motor coordination was evaluated using an accelerating RotaRod apparatus.
Ongoing pain-like behaviour was assessed via spontaneous burrowing and nocturnal wheel running.
Mechanical and cold hypersensitivity developed after a delayed onset, peaked approximately on day 28, and persisted for several months.
Heat sensitivity and motor coordination were unaltered in paclitaxel-treated rats.
Spontaneous burrowing behaviour and nocturnal wheel running were significantly impaired on day 28, but not on day 7, indicating ongoing pain-like behaviour, rather than acute drug toxicity.
This study comprehensively characterises a rat model of paclitaxel-induced peripheral neuropathy, providing the first evidence for ongoing pain-like behaviour, which occurs in parallel with maximal mechanical/cold hypersensitivity.
We hope that this new data improve the face validity of rat models to better reflect patient-reported pain symptoms, aiding translation of new treatments to the clinic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Griffiths, Lisa A.& Duggett, Natalie A.& Pitcher, Ann L.& Flatters, Sarah J. L.. 2018. Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy. Pain Research and Management،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212610
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Griffiths, Lisa A.…[et al.]. Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy. Pain Research and Management No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1212610
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Griffiths, Lisa A.& Duggett, Natalie A.& Pitcher, Ann L.& Flatters, Sarah J. L.. Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212610
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212610
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر