Outcome for Advanced or Metastatic Soft Tissue Sarcoma of Nonextremities Treated with Doxorubicin-Based Chemotherapy: A Retrospective Study from a Single Cancer Institution
المؤلفون المشاركون
Marshall, Shoko
Nakano, Kenji
Sugiura, Yoshiya
Taira, Shinichiro
Ono, Makiko
Tomomatsu, Junichi
Takahashi, Shunji
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Doxorubicin is the key drug for treatment of advanced soft tissue sarcoma (STS).
The appropriate dosage of doxorubicin, regarding monotherapy or the role of combination therapy, is unclear.
Methods.
We retrospectively reviewed patients with advanced or metastatic STS of nonextremities who were treated with doxorubicin-based chemotherapies in our institution.
Time to treatment failure (TTF), overall survival (OS), overall response, and prognostic factors for OS were evaluated.
Results.
Seventy-five patients were enrolled.
The median TTF was 4.7 months, and the median OS was 20.1 months.
The overall response rate was 20%.
Doses of doxorubicin monotherapy did not show significant difference either in TTF or in OS.
There were no significant differences in OS between combination therapy and monotherapy, but the TTF with combination therapy was better than monotherapy.
The overall response for combination therapy indicated a better response rate.
Less number of involved organs, no bulky mass, and a normal CRP level were independent favorable prognostic factors for OS.
Conclusions.
Combination therapy showed better response and TTF than monotherapy but did not show better OS.
Possible prognostic factors for OS were indicated.
This retrospective study was approved by the institutional review board.
This trial is registered with UMIN000028787.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marshall, Shoko& Nakano, Kenji& Sugiura, Yoshiya& Taira, Shinichiro& Ono, Makiko& Tomomatsu, Junichi…[et al.]. 2018. Outcome for Advanced or Metastatic Soft Tissue Sarcoma of Nonextremities Treated with Doxorubicin-Based Chemotherapy: A Retrospective Study from a Single Cancer Institution. Complexity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212842
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marshall, Shoko…[et al.]. Outcome for Advanced or Metastatic Soft Tissue Sarcoma of Nonextremities Treated with Doxorubicin-Based Chemotherapy: A Retrospective Study from a Single Cancer Institution. Complexity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212842
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marshall, Shoko& Nakano, Kenji& Sugiura, Yoshiya& Taira, Shinichiro& Ono, Makiko& Tomomatsu, Junichi…[et al.]. Outcome for Advanced or Metastatic Soft Tissue Sarcoma of Nonextremities Treated with Doxorubicin-Based Chemotherapy: A Retrospective Study from a Single Cancer Institution. Complexity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212842
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212842
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر