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The Hypoxia-Mimetic Agent Cobalt Chloride Differently Affects Human Mesenchymal Stem Cells in Their Chondrogenic Potential
المؤلفون المشاركون
Falconi, Mirella
Focaroli, Stefano
Teti, Gabriella
Salvatore, Viviana
Mazzotti, Eleonora
Ingra’, Laura
Mazzotti, Antonio
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-13
دولة النشر
مصر
عدد الصفحات
9
الملخص EN
Adult stem cells are a promising cell source for cartilage regeneration.
They resided in a special microenvironment known as the stem-cell niche, characterized by the presence of low oxygen concentration.
Cobalt chloride (CoCl2) imitates hypoxia in vitro by stabilizing hypoxia-inducible factor-alpha (HIF-1α), which is the master regulator in the cellular adaptive response to hypoxia.
In this study, the influence of CoCl2 on the chondrogenic potential of human MSCs, isolated from dental pulp, umbilical cord, and adipose tissue, was investigated.
Cells were treated with concentrations of CoCl2 ranging from 50 to 400 μM.
Cell viability, HIF-1α protein synthesis, and the expression of the chondrogenic markers were analyzed.
The results showed that the CoCl2 supplementation had no effect on cell viability, while the upregulation of chondrogenic markers such as SOX9, COL2A1, VCAN, and ACAN was dependent on the cellular source.
This study shows that hypoxia, induced by CoCl2 treatment, can differently influence the behavior of MSCs, isolated from different sources, in their chondrogenic potential.
These findings should be taken into consideration in the treatment of cartilage repair and regeneration based on stem cell therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Teti, Gabriella& Focaroli, Stefano& Salvatore, Viviana& Mazzotti, Eleonora& Ingra’, Laura& Mazzotti, Antonio…[et al.]. 2018. The Hypoxia-Mimetic Agent Cobalt Chloride Differently Affects Human Mesenchymal Stem Cells in Their Chondrogenic Potential. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213324
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Teti, Gabriella…[et al.]. The Hypoxia-Mimetic Agent Cobalt Chloride Differently Affects Human Mesenchymal Stem Cells in Their Chondrogenic Potential. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213324
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Teti, Gabriella& Focaroli, Stefano& Salvatore, Viviana& Mazzotti, Eleonora& Ingra’, Laura& Mazzotti, Antonio…[et al.]. The Hypoxia-Mimetic Agent Cobalt Chloride Differently Affects Human Mesenchymal Stem Cells in Their Chondrogenic Potential. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213324
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213324
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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