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Quiescent Human Mesenchymal Stem Cells Are More Resistant to Heat Stress than Cycling Cells
المؤلفون المشاركون
Lyublinskaya, O. G.
Vinogradov, A. E.
Shilina, M. A.
Anatskaya, O. V.
Alekseenko, L. L.
Fridlyanskaya, I. I.
Grinchuk, T. M.
Kornienko, J. S.
Nikolsky, N. N.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-24
دولة النشر
مصر
عدد الصفحات
15
الملخص EN
Quiescence is the prevailing state of many cell types under homeostatic conditions.
Yet, surprisingly, little is known about how quiescent cells respond to environmental challenges.
The aim of the present study is to compare stress responses of cycling and quiescent mesenchymal stem cells (MSC).
Human endometrial mesenchymal cells (eMSС) were employed as adult stem cells.
eMSC quiescence was modeled by serum starvation.
Sublethal heat shock (HS) was used as a stress factor.
Both quiescent and cycling cells were heated at 45°C for 30 min and then returned to standard culture conditions for their recovery.
HS response was monitored by DNA damage response, stress-induced premature senescence (SIPS), cell proliferation activity, and oxidative metabolism.
It has been found that quiescent cells repair DNA more rapidly, resume proliferation, and undergo SIPS less than proliferating cells.
HS-enforced ROS production in heated cycling cells was accompanied with increased expression of genes regulating redox-active proteins.
Quiescent cells exposed to HS did not intensify the ROS production, and genes involved in antioxidant defense were mostly silent.
Altogether, the results have shown that quiescent cells are more resistant to heat stress than cycling cells.
Next-generation sequencing (NGS) demonstrates that HS-survived cells retain differentiation capacity and do not exhibit signs of spontaneous transformation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alekseenko, L. L.& Shilina, M. A.& Lyublinskaya, O. G.& Kornienko, J. S.& Anatskaya, O. V.& Vinogradov, A. E.…[et al.]. 2018. Quiescent Human Mesenchymal Stem Cells Are More Resistant to Heat Stress than Cycling Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1213364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alekseenko, L. L.…[et al.]. Quiescent Human Mesenchymal Stem Cells Are More Resistant to Heat Stress than Cycling Cells. Stem Cells International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1213364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alekseenko, L. L.& Shilina, M. A.& Lyublinskaya, O. G.& Kornienko, J. S.& Anatskaya, O. V.& Vinogradov, A. E.…[et al.]. Quiescent Human Mesenchymal Stem Cells Are More Resistant to Heat Stress than Cycling Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1213364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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