Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α
المؤلفون المشاركون
Tang, Xiaojun
Yao, Genghong
Chen, Weiwei
Li, Wenchao
Sun, Lingyun
Liu, Chang
Zhang, Huayong
Feng, Ruihai
Liang, Jun
Feng, Xuebing
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-08
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Objective.
To investigate the effects of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on joint damage and osteoporosis in collagen-induced arthritis (CIA) mice and to explore the mechanisms by which UC-MSCs modulate the osteogenic differentiation.
Methods.
CIA mice were divided into the following treated groups: UC-MSC transplantation group, antitumor necrosis factor- (TNF-) α group, and zoledronic acid (ZA) group.
Microcomputed tomography (micro-CT) was used to analyze the bone morphology parameters.
Osteogenic differentiation of treated CIA mice was determined.
Bone marrow mesenchymal stem cells (BM-MSCs) from CIA mice were treated with TNF-α in vitro to explore their effects on osteogenesis.
Results.
The arthritis score was significantly reduced in the UC-MSC transplantation and anti-TNF-α-treated CIA groups, compared with control mice (P<0.001).
Micro-CT showed that CIA mice developed osteoporosis at 12 weeks after immunization.
The bone morphology parameters were partially improved in UC-MSC-treated CIA mice.
Impaired osteogenic differentiation functions were indicated by decreased ALP activity (P<0.001) and reduced mRNA and protein levels of osteogenic marker genes (P<0.05) in CIA mice compared with DBA/1 mice.
UC-MSC treatment significantly upregulated the impaired osteogenic differentiation ability in CIA mice.
Meanwhile, the serum TNF-α level was decreased significantly in the UC-MSC group.
The osteogenesis was reduced with the addition of TNF-α in vitro.
Conclusion.
This study demonstrated that UC-MSC transplantation not only significantly improved the joint damage but also played a beneficial role in osteoporosis in CIA mice.
Mechanistically, the improved osteogenic differentiation of CIA under UC-MSC treatment may be achieved by inhibition of TNF-α.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Chang& Zhang, Huayong& Tang, Xiaojun& Feng, Ruihai& Yao, Genghong& Chen, Weiwei…[et al.]. 2018. Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213370
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Chang…[et al.]. Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213370
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Chang& Zhang, Huayong& Tang, Xiaojun& Feng, Ruihai& Yao, Genghong& Chen, Weiwei…[et al.]. Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213370
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213370
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر