Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions
المؤلفون المشاركون
Südkamp, Norbert P.
Seidenstuecker, Michael
Bernstein, Anke
Kubosch, Eva J.
Kowal, Justyna M.
Böttiger, Katharina
Xiong, Tanshiyue
Kassem, Moustapha
Schmal, Hagen
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-19
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives.
The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation.
In an osteochondral defect model of the medial femoral condyle in a rabbit, a collagen membrane was seeded with either culture-expanded allogenic chondrocytes or SMSC and then transplanted into the lesion.
A tailored piece synovium served as a control.
Rabbit SMSC formed typical cartilage in vitro.
Macroscopic evaluation of defect healing and the thickness of the regenerated tissue did not reveal a significant difference between the intervention groups.
However, instantaneous and shear modulus, reflecting the biomechanical strength of the repair tissue, was superior in the implantation group using allogenic chondrocytes (p<0.05).
This correlated with a more chondrogenic structure and higher proteoglycan expression, resulting in a lower OARSI score (p<0.05).
The repair tissue of all groups expressed comparable amounts of the collagen types I, II, and X.
Cartilage regeneration following matrix-associated implantation using allogenic undifferentiated synovium-derived stem cells in a defect model in rabbits showed similar macroscopic results and collagen composition compared to amplified chondrocytes; however, biomechanical characteristics and histological scoring were inferior.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schmal, Hagen& Kowal, Justyna M.& Kassem, Moustapha& Seidenstuecker, Michael& Bernstein, Anke& Böttiger, Katharina…[et al.]. 2018. Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions. Stem Cells International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schmal, Hagen…[et al.]. Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions. Stem Cells International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1213381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schmal, Hagen& Kowal, Justyna M.& Kassem, Moustapha& Seidenstuecker, Michael& Bernstein, Anke& Böttiger, Katharina…[et al.]. Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر