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Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches
المؤلفون المشاركون
Qu, Hui
Xie, Bao-dong
Lv, Bo
Chuai, Jun-bo
Li, Jian-zhong
Cai, Jun
Wu, Hua
Jiang, Shu-lin
Leng, Xiao-ping
Kang, Kai
Wu, Jian
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-13
دولة النشر
مصر
عدد الصفحات
16
الملخص EN
Background.
Engineered heart tissues (EHTs) present a promising alternative to current materials for surgical ventricular restoration (SVR); however, the clinical application remains limited by inadequate vascularization postimplantation.
Moreover, a suitable and economic animal model for primary screening is another important issue.
Methods.
Recently, we used 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride chemistry (EDC) to initiate a strengthened, cytokine-conjugated collagenous platform with a controlled degradation speed.
In vitro, the biomaterial exhibited an enhanced mechanical strength maintaining a porous ultrastructure, and the constant release of cytokines promoted the proliferation of seeded human mesenchymal stem cells (hMSCs).
In vivo, with the hMSC-seeded, cytokine-immobilized patch (MSCs + GF patch), we performed modified SVR for rats with left ventricular aneurysm postmyocardial infarction (MI).
Overall, the rats that underwent modified SVR lost less blood and had lower mortality.
After 4 weeks, the rats repaired with this cell-seeded, cytokine-immobilized patch presented preserved cardiac function, beneficial morphology, enhanced cell infiltration, and functional vessel formation compared with the cytokine-free (MSC patch), cell-free (GF patch), or blank controls (EDC patch).
Furthermore, the degradable period of the collagen patch in vivo extended up to 3 months after EDC treatment.
Conclusions.
EDC may substantially modify collagen scaffold and provide a promising and practical biomaterial for SVR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qu, Hui& Xie, Bao-dong& Wu, Jian& Lv, Bo& Chuai, Jun-bo& Li, Jian-zhong…[et al.]. 2018. Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches. Stem Cells International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qu, Hui…[et al.]. Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches. Stem Cells International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1213429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qu, Hui& Xie, Bao-dong& Wu, Jian& Lv, Bo& Chuai, Jun-bo& Li, Jian-zhong…[et al.]. Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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