Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches
المؤلفون المشاركون
Qu, Hui
Xie, Bao-dong
Lv, Bo
Chuai, Jun-bo
Li, Jian-zhong
Cai, Jun
Wu, Hua
Jiang, Shu-lin
Leng, Xiao-ping
Kang, Kai
Wu, Jian
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-13
دولة النشر
مصر
عدد الصفحات
16
الملخص EN
Background.
Engineered heart tissues (EHTs) present a promising alternative to current materials for surgical ventricular restoration (SVR); however, the clinical application remains limited by inadequate vascularization postimplantation.
Moreover, a suitable and economic animal model for primary screening is another important issue.
Methods.
Recently, we used 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride chemistry (EDC) to initiate a strengthened, cytokine-conjugated collagenous platform with a controlled degradation speed.
In vitro, the biomaterial exhibited an enhanced mechanical strength maintaining a porous ultrastructure, and the constant release of cytokines promoted the proliferation of seeded human mesenchymal stem cells (hMSCs).
In vivo, with the hMSC-seeded, cytokine-immobilized patch (MSCs + GF patch), we performed modified SVR for rats with left ventricular aneurysm postmyocardial infarction (MI).
Overall, the rats that underwent modified SVR lost less blood and had lower mortality.
After 4 weeks, the rats repaired with this cell-seeded, cytokine-immobilized patch presented preserved cardiac function, beneficial morphology, enhanced cell infiltration, and functional vessel formation compared with the cytokine-free (MSC patch), cell-free (GF patch), or blank controls (EDC patch).
Furthermore, the degradable period of the collagen patch in vivo extended up to 3 months after EDC treatment.
Conclusions.
EDC may substantially modify collagen scaffold and provide a promising and practical biomaterial for SVR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qu, Hui& Xie, Bao-dong& Wu, Jian& Lv, Bo& Chuai, Jun-bo& Li, Jian-zhong…[et al.]. 2018. Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches. Stem Cells International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qu, Hui…[et al.]. Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches. Stem Cells International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1213429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qu, Hui& Xie, Bao-dong& Wu, Jian& Lv, Bo& Chuai, Jun-bo& Li, Jian-zhong…[et al.]. Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر