Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells

الملخص EN

Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence.

However, there are no promising therapeutics directed against CSCs.

Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-renewal.

miR-503-3p, isolated from human adipose stem cell- (ASC-) derived exosomes, suppressed initiation and progression of CSCs as determined by anchorage-dependent (colony formation) and anchorage-independent (tumorsphere formation) assays.

The expression of pluripotency genes was significantly decreased in miR-503-3p-treated CSCs.

Furthermore, xenografts, which received miR-503-3p, exhibited remarkably reduced tumor growth in vivo.

Thus, miR-503-3p may function as a stemness-attenuating factor via cell-to-cell communications.