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Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction
المؤلفون المشاركون
Senegaglia, Alexandra Cristina
Leite, Lidiane Maria Boldrini
Capriglione, Luiz Guilherme A.
Brofman, Paulo
Correa, Alejandro
Ottoboni, Gabriel Salles
Miyague, Nelson Itiro
Jamur, Valderez Ravaglio
Rebelatto, Carmen Lúcia Kuniyoshi
Olandoski, Márcia
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-11
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Pharmacological approaches are partially effective in limiting infarct size.
Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs) CD133+ have opened new perspectives for the treatment of ischemic areas after infarction.
This preclinical study evaluated the effect of intramyocardial transplantation of purified or expanded human umbilical cord blood-derived CD133+ cells on the recovery of rats following acute myocardial infarction (AMI).
Histology studies, electrocardiogram, and fluorescence in situ hybridization (FISH) were used to evaluate heart recovery.
Purified CD133+ cells, enriched in endothelial progenitor cells, when expanded in vitro acquired an endothelial-like cell phenotype expressing CD31 and von Willebrand factor (vWF).
The group of infarcted rats that received expanded CD133+ cells had a more significant recovery of contraction performance and less heart remodeling than the group that received purified CD133+ cells.
Either purified or expanded CD133+ cells were able to induce neovascularization in the infarcted myocardium in an equivalent manner.
Few human cells were detected in the infarcted myocardium of the rats 28 days after transplantation suggesting that the effects observed might be related primarily to paracrine activity.
Although both cell populations ameliorated the infarcted heart and are suitable for regeneration of the vascular system, expanded CD133+ cells are more beneficial and promising candidates for vascular regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Correa, Alejandro& Ottoboni, Gabriel Salles& Senegaglia, Alexandra Cristina& Capriglione, Luiz Guilherme A.& Miyague, Nelson Itiro& Leite, Lidiane Maria Boldrini…[et al.]. 2018. Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Correa, Alejandro…[et al.]. Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Correa, Alejandro& Ottoboni, Gabriel Salles& Senegaglia, Alexandra Cristina& Capriglione, Luiz Guilherme A.& Miyague, Nelson Itiro& Leite, Lidiane Maria Boldrini…[et al.]. Expanded CD133+ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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