Exosomal MicroRNAs Derived from Human Amniotic Epithelial Cells Accelerate Wound Healing by Promoting the Proliferation and Migration of Fibroblasts
المؤلفون المشاركون
Zhao, Bin
Li, Xiaodong
Shi, Xiaomin
Shi, Xueqin
Zhang, Wei
Wu, Gaofeng
Wang, Xujie
Su, Linlin
Hu, Dahai
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-25
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Previous work in our laboratory demonstrated that exosomes derived from human amniotic epithelial cells (hAECs) accelerated wound healing by promoting the proliferation and migration of fibroblasts.
It is reported that exosomes, which are carriers of the microRNAs (miRNAs) and proteins, play an important role in the regulation of cell-to-cell communication.
However, it is still unclear precisely which molecule or which group of molecules carried within hAEC-derived exosomes (hAEC-Exos) mediated wound healing.
Here, we explored purified hAEC-Exos together with either proteinase K (PROse) or RNase A on the effect of fibroblasts and cutaneous wound healing.
Our experiments demonstrated that hAEC-Exos were positive for exosomal markers CD9, CD63, and CD81.
Also, we found that hAEC-Exos could be internalized by fibroblasts and then stimulated cell migration and proliferation.
However, the promotive effect of hAEC-Exos was abolished by pretreating hAEC-Exos with RNase A, not PROse.
Importantly, in vivo wound healing assay showed that local injection of hAEC-Exos or PROse pretreated hAEC-Exos at skin wounds significantly accelerated wound healing.
Our findings revealed an important role of exosomal miRNAs in wound healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Bin& Li, Xiaodong& Shi, Xiaomin& Shi, Xueqin& Zhang, Wei& Wu, Gaofeng…[et al.]. 2018. Exosomal MicroRNAs Derived from Human Amniotic Epithelial Cells Accelerate Wound Healing by Promoting the Proliferation and Migration of Fibroblasts. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213472
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Bin…[et al.]. Exosomal MicroRNAs Derived from Human Amniotic Epithelial Cells Accelerate Wound Healing by Promoting the Proliferation and Migration of Fibroblasts. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213472
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Bin& Li, Xiaodong& Shi, Xiaomin& Shi, Xueqin& Zhang, Wei& Wu, Gaofeng…[et al.]. Exosomal MicroRNAs Derived from Human Amniotic Epithelial Cells Accelerate Wound Healing by Promoting the Proliferation and Migration of Fibroblasts. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213472
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213472
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر