Mesenchymal Stem Cells in Oriented PLGAACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model
المؤلفون المشاركون
Guo, Weimin
Wang, Ai-Yuan
Xu, Wen-Jing
Guo, Quan-Yi
Lu, Shi-Bi
Wang, Yu
Huang, Jingxiang
Yuan, Zhiguo
Sui, Xiang
Chen, Mingxue
Wang, Mingjie
Hao, Chunxiang
Wang, Zhenyong
Zhang, Yu
Peng, Jiang
Zheng, Xifu
Zhang, Weiguo
Liu, Shuyun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-13
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
Articular cartilage lacks a blood supply and nerves.
Hence, articular cartilage regeneration remains a major challenge in orthopedics.
Decellularized extracellular matrix- (ECM-) based strategies have recently received particular attention.
The structure of native cartilage exhibits complex zonal heterogeneity.
Specifically, the development of a tissue-engineered scaffold mimicking the aligned structure of native cartilage would be of great utility in terms of cartilage regeneration.
Previously, we fabricated oriented PLGA/ACECM (natural, nanofibrous, articular cartilage ECM) composite scaffolds.
In vitro, we found that the scaffolds not only guided seeded cells to proliferate in an aligned manner but also exhibited high biomechanical strength.
To detect whether oriented cartilage regeneration was possible in vivo, we used mesenchymal stem cell (MSC)/scaffold constructs to repair cartilage defects.
The results showed that cartilage defects could be completely regenerated.
Histologically, these became filled with hyaline cartilage and subchondral bone.
Moreover, the aligned structure of cartilage was regenerated and was similar to that of native tissue.
In conclusion, the MSC/scaffold constructs enhanced the structure-specific regeneration of hyaline cartilage in a rabbit model and may be a promising treatment strategy for the repair of human cartilage defects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Weimin& Zheng, Xifu& Zhang, Weiguo& Chen, Mingxue& Wang, Zhenyong& Hao, Chunxiang…[et al.]. 2018. Mesenchymal Stem Cells in Oriented PLGAACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model. Stem Cells International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213521
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Weimin…[et al.]. Mesenchymal Stem Cells in Oriented PLGAACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model. Stem Cells International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1213521
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Weimin& Zheng, Xifu& Zhang, Weiguo& Chen, Mingxue& Wang, Zhenyong& Hao, Chunxiang…[et al.]. Mesenchymal Stem Cells in Oriented PLGAACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213521
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213521
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر