Mesenchymal Stem Cells Enhance Liver Regeneration via Improving Lipid Accumulation and Hippo Signaling

الملخص EN

The liver has the potential to regenerate after injury.

It is a challenge to improve liver regeneration (LR) after liver resection in clinical practice.

Bone morrow-derived mesenchymal stem cells (MSCs) have shown to have a role in various liver diseases.

To explore the effects of MSCs on LR, we established a model of 70% partial hepatectomy (PHx).

Results revealed that infusion of MSCs could improve LR through enhancing cell proliferation and cell growth during the first 2 days after PHx, and MSCs could also restore liver synthesis function.

Infusion of MSCs also improved liver lipid accumulation partly via mechanistic target of rapamycin (mTOR) signaling and enhanced lipid β-oxidation support energy for LR.

Rapamycin-induced inhibition of mTOR decreased liver lipid accumulation at 24 h after PHx, leading to impaired LR.

And after infusion of MSCs, a proinflammatory environment formed in the liver, evidenced by increased expression of IL-6 and IL-1β, and thus the STAT3 and Hippo-YAP pathways were activated to improve cell proliferation.

Our results demonstrated the function of MSCs on LR after PHx and provided new evidence for stem cell therapy of liver diseases.