![](/images/graphics-bg.png)
Injection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap after Unilateral Vocal Fold Paralysis
المؤلفون المشاركون
Fernández Santos, María Eugenia
Lasso, José M.
Poletti, Daniel
Scola, Batolomé
Gómez-Vilda, Pedro
García-Martín, Ana I.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-15
دولة النشر
مصر
عدد الصفحات
15
الملخص EN
Background.
Paralysis of one vocal fold leads to glottal gap and vocal fold insufficiency that has significant impact upon a patient’s quality of life.
Fillers have been tested to perform intracordal injections, but they do not provide perdurable results.
Early data suggest that enriching fat grafts with adipose-derived regenerative cells (ADRCs) promote angiogenesis and modulate the immune response, improving graft survival.
The aim of this study is to propose ADRC-enriched adipose tissue grafts as effective filler for the paralyzed vocal fold to use it for functional reconstruction of the glottal gap.
Method.
This is the first phase I-IIA clinical trial (phase I/IIA clinical trial, unicentric, randomized, controlled, and two parallel groups), to evaluate the safety of a new therapy with ADRC-enriched fat grafting (ADRC: group I) for laryngoplasty after unilateral vocal fold paralysis.
Control group patients received centrifuged autologous fat (CAF: group II) grafts.
Overall mean age is 52.49 ± 16.60 years.
Group I (ADRC): 7 patients (3 males and 4 females), 52.28 ± 20.95 year.
Group II (CAF): 7 patients (3 males and 4 females), 52.71 ± 12.59 year.
Results.
VHI-10 test showed that preoperative mean score was 24.21 ± 8.28.
Postoperative mean score was 6.71 ± 6.75.
Preoperative result in group I was 21.14 ± 3.58 and postoperative result was 3.14 ± 3.53.
Preoperative result for group II was 27.29 ± 10.66.
Postoperative score in group II was 10.29 ± 7.52.
Wilcoxon and the Student t-tests showed that the patient’s self-perception of posttreatment improvement is larger when ADRCs are used.
Comparing pre- and posttreatment voice quality analysis, group I showed a p=0.053.
Group II showed a p=0.007.
There would be no significant differentiation between pre- and posttreatment results.
This is true for group II and limited for group I.
Conclusions.
This prospective trial demonstrates the safety and efficacy of the treatment of glottal gap defects utilizing ADRC-enriched fat grafts.
This trial is registered with NCT02904824.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lasso, José M.& Poletti, Daniel& Scola, Batolomé& Gómez-Vilda, Pedro& García-Martín, Ana I.& Fernández Santos, María Eugenia. 2018. Injection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap after Unilateral Vocal Fold Paralysis. Stem Cells International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1213617
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lasso, José M.…[et al.]. Injection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap after Unilateral Vocal Fold Paralysis. Stem Cells International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1213617
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lasso, José M.& Poletti, Daniel& Scola, Batolomé& Gómez-Vilda, Pedro& García-Martín, Ana I.& Fernández Santos, María Eugenia. Injection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap after Unilateral Vocal Fold Paralysis. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1213617
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213617
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)