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Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients
المؤلفون المشاركون
Pölönen, Risto-Pekka
Penttinen, K.
Swan, H.
Aalto-Setala, K.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-12
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for catecholaminergic polymorphic ventricular tachycardia (CPVT).
In this study, we evaluated antiarrhythmic efficacy of carvedilol and flecainide in CPVT patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carrying different mutations in RYR2.
iPSC-CMs were generated from skin biopsies of CPVT patients carrying exon 3 deletion and L4115 or V4653F mutation in RYR2 and of a healthy individual.
Ca2+ kinetics and drug effects were studied with Fluo-4 AM indicator.
Carvedilol abolished Ca2+ abnormalities in 31% of L4115F, 36% of V4653F, and 46% of exon 3 deletion carrying CPVT cardiomyocytes and flecainide 33%, 30%, and 52%, respectively.
Both drugs lowered the intracellular Ca2+ level and beating rate of the cardiomyocytes significantly.
Moreover, flecainide caused abnormal Ca2+ transients in 61% of controls compared to 26% of those with carvedilol.
Carvedilol and flecainide were equally effective in CPVT iPSC-CMs.
However, flecainide induced arrhythmias in 61% of control cells.
CPVT cardiomyocytes carrying the exon 3 deletion had the most severe Ca2+ abnormalities, but they had the best response to drug therapies.
According to this study, the arrhythmia-abolishing effect of neither of the drugs is optimal.
iPSC-CMs provide a unique platform for testing drugs for CPVT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pölönen, Risto-Pekka& Penttinen, K.& Swan, H.& Aalto-Setala, K.. 2018. Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pölönen, Risto-Pekka…[et al.]. Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pölönen, Risto-Pekka& Penttinen, K.& Swan, H.& Aalto-Setala, K.. Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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