Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct Cortices of dMCAO Rats
المؤلفون المشاركون
Chen, Zhiguo
Guan, Yunqian
Li, Xiaobo
Yu, Wenxiu
Liang, Zhaohui
Huang, Min
Zhao, Renchao
Zhao, Chunsong
Liu, Yao
Zou, Haiqiang
Hao, Yanli
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-02
دولة النشر
مصر
عدد الصفحات
14
الملخص EN
The resident microglial and infiltrating cells from peripheral circulation are involved in the pathological processes of ischemia stroke and may be regulated by mesenchymal stem/stromal cell (MSC) transplantation.
The present study is aimed at differentiating the neurotrophic and inflammatory roles played by microglial vs.
infiltrating circulation-derived cells in the acute phase in rat ischemic brains and explore the influences of intravenously infused allogeneic MSCs.
The ischemic brain injury was induced by distal middle cerebral artery occlusion (dMCAO) in SD rats, with or without MSC infusion in the same day following dMCAO.
Circulation-derived infiltrating cells in the brain were identified by Ly6C, a majority of which were monocytes/macrophages.
Without MSC transplantation, among the infiltrated Ly6C+ cells, some were positive for BDNF, IL-1β, or TNF-α.
Following MSC infusion, the overall number of Ly6C+ infiltrated cells was reduced by 50%.
In contrast, the proportions of infiltrated Ly6C+ cells coexpressing BDNF, IL-1β, or TNF-α were significantly enhanced.
Interestingly, Ly6C+ cells in the infarct area could produce either neurotrophic factor BDNF or inflammatory cytokines (IL-1β or TNF-α), but not both.
This suggests that the Ly6C+ cells may constitute heterogeneous populations which react differentially to the microenvironments in the infarct area.
The changes in cellular composition in the infarct area may have contributed to the beneficial effect of MSC transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guan, Yunqian& Li, Xiaobo& Yu, Wenxiu& Liang, Zhaohui& Huang, Min& Zhao, Renchao…[et al.]. 2018. Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct Cortices of dMCAO Rats. Stem Cells International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213657
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guan, Yunqian…[et al.]. Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct Cortices of dMCAO Rats. Stem Cells International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1213657
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guan, Yunqian& Li, Xiaobo& Yu, Wenxiu& Liang, Zhaohui& Huang, Min& Zhao, Renchao…[et al.]. Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct Cortices of dMCAO Rats. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213657
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213657
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر