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Current Progress in the Rejuvenation of Aging StemProgenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair
المؤلفون المشاركون
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-29
دولة النشر
مصر
عدد الصفحات
9
الملخص EN
Ischemic heart disease affects a majority of people, especially elderly patients.
Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction.
However, donor cells from aging patients are more likely to be in a senescent stage.
Rejuvenation is required to reverse the damage levied by aging and promote a youthful phenotype.
This review aims to discuss current strategies that are effective in rejuvenating aging cardiac stem cells and represent novel therapeutic methods to treat the aging heart.
Recent literature mainly focuses on three approaches that aim to reverse cardiac aging: genetic modification, pharmaceutical administration, and optimization of extracellular factors.
In vitro genetic modification can be used to overexpress or knock down certain genes and allow for reversal of the aging phenotype.
Pharmaceutical administration is another approach that allows for manipulation of signaling pathways related to cell proliferation and cell senescence.
Since the stem cell niche can contribute to the age-related decline in stem cell function, rejuvenation strategies also include optimization of extracellular factors.
Overall, improving the intrinsic properties of aging stem cells as well as the surrounding environment allows these cells to adopt a phenotype similar to their younger counterparts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaur, Gurleen& Cai, Chuanxi. 2018. Current Progress in the Rejuvenation of Aging StemProgenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213667
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaur, Gurleen& Cai, Chuanxi. Current Progress in the Rejuvenation of Aging StemProgenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213667
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaur, Gurleen& Cai, Chuanxi. Current Progress in the Rejuvenation of Aging StemProgenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213667
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213667
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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