A New T. gondii Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease

المؤلفون المشاركون

Pletnikov, Mikhail V.
Prandovszky, Emese
Severance, Emily G.
Yolken, Robert H.
Kannan, Geetha

المصدر

Scientifica

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-12-02

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض

الملخص EN

Infection with the protozoan parasite, Toxoplasma gondii (T.

gondii), was linked to several psychiatric disorders.

The exact mechanisms of a hypothesized contribution of T.

gondii infection are poorly understood, and it appears that only a subset of seropositive individuals go on to develop a mental illness, suggesting genetic vulnerability.

In order to stimulate mechanistic studies of how exposure to T.

gondii could interact with genetic predisposition to psychiatric disorders, we have generated and characterized a mouse model of chronic T.

gondii infection in BALB/c mice with inducible forebrain neuronal expression of a C-terminus truncated dominant-negative form of disrupted-in-schizophrenia 1 (DN-DISC1).

In this gene-environment interaction (GxE) model, exposing control and DN-DISC1 male and female mice to T.

gondii produced sex-dependent abnormalities in locomotor activity and prepulse inhibition of the acoustic startle.

No genotype- or sex-dependent effects were found on levels of anti-Toxoplasma IgG antibodies or anti-NMDAR or C1q antibodies.

Our work demonstrates that a psychiatric genetic risk factor, DN-DISC1, modulates the neurobehavioral effects of chronic T.

gondii infection in a sex-dependent manner.

The present T.

gondii model of GxE provides a valuable experimental system for future mechanistic studies and evaluation of new treatments.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kannan, Geetha& Prandovszky, Emese& Severance, Emily G.& Yolken, Robert H.& Pletnikov, Mikhail V.. 2018. A New T. gondii Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease. Scientifica،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213779

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kannan, Geetha…[et al.]. A New T. gondii Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease. Scientifica No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213779

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kannan, Geetha& Prandovszky, Emese& Severance, Emily G.& Yolken, Robert H.& Pletnikov, Mikhail V.. A New T. gondii Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease. Scientifica. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213779

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1213779