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Identification of Novel Bioactive Compound Derived from Rheum officinalis against Campylobacter jejuni NCTC11168
المؤلفون المشاركون
Yosri, Mohammed
Amin, Basma H.
Abed, Nermine N.
Elithy, Amal S.
Kareem, Sayed M.
Sidkey, Nagwa M.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Gastric diseases are increasing with the infection of Campylobacter jejuni.
Late stages of infection lead to peptic ulcer and gastric carcinoma.
C.
jejuni infects people within different stages of their life, especially childhood, causing severe diarrhea; it infects around two-thirds of the world population.
Due to bacterial resistance against standard antibiotic, a new strategy is needed to impede Campylobacter infections.
Plants provide highly varied structures with antimicrobial use which are unlikely to be synthesized in laboratories.
A special feature of higher plants is their ability to produce a great number of organic chemicals of high structural diversity, the so-called secondary metabolites.
Twenty plants were screened to detect their antibacterial activities.
Screening results showed that Rheum officinalis was the most efficient against C.
jejuni.
Fractionation pattern was obtained by column chromatography, while the purity test was done by thin-layer chromatography (TLC).
The chemical composition of bioactive compound was characterized using GC-MS, nuclear magnetic resonance, and infrared analysis.
Minimal inhibitory concentration (MIC) of the purified compound was 31.25 µg/ml.
Cytotoxicity assay on Vero cells was evaluated to be 497 µg/ml.
Furthermore, the purified bioactive compound activated human lymphocytes in vitro.
The data presented here show that Rheum officinalis could potentially be used in modern applications aimed at the treatment or prevention of foodborne diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yosri, Mohammed& Amin, Basma H.& Abed, Nermine N.& Elithy, Amal S.& Kareem, Sayed M.& Sidkey, Nagwa M.. 2020. Identification of Novel Bioactive Compound Derived from Rheum officinalis against Campylobacter jejuni NCTC11168. The Scientific World Journal،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1213868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yosri, Mohammed…[et al.]. Identification of Novel Bioactive Compound Derived from Rheum officinalis against Campylobacter jejuni NCTC11168. The Scientific World Journal No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1213868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yosri, Mohammed& Amin, Basma H.& Abed, Nermine N.& Elithy, Amal S.& Kareem, Sayed M.& Sidkey, Nagwa M.. Identification of Novel Bioactive Compound Derived from Rheum officinalis against Campylobacter jejuni NCTC11168. The Scientific World Journal. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1213868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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