Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study
المؤلفون المشاركون
Arita, Shinji
Arita, Noboru
Hikasa, Yoshiaki
المصدر
Veterinary Medicine International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Eplerenone (EP), an aldosterone antagonist, is reported to produce renal and cardiac protective effects in noncanine species.
However, there are no detailed reports available on cardiovascular effects of EP in dogs.
This study aimed to determine effect of EP on echocardiographic parameters, blood pressures, and biochemical variables in healthy dogs.
Five healthy Beagle dogs were randomly divided and repeatedly used in each of 3 dose groups, receiving 2.5, 5, or 10 mg/kg BW EP orally q24 h for 4 wks.
Serum biochemical test, blood pressure, and Doppler echocardiography measurements were performed before EP administration and at 1, 2, and 4 weeks after EP administration.
Treatment with EP reduced mean blood pressure in a dose-dependent manner and significantly (but in a dose-independent manner) decreased left atrium/aorta ratio, early diastolic transmitral flow, early diastolic transmitral flow/late diastolic transmitral flow, peak velocity of early diastolic transmitral flow/peak velocity of early diastolic mitral annular motion, left ventricle and right ventricle Tei indices, stroke volume, cardiac output, and mid systole myocardial velocity gradient 1 to 4 weeks after administration.
Deceleration time of early diastolic transmitral flow significantly increased after EP administration.
No significant changes were observed in serum biochemical variables.
The results indicated that EP might reduce preload, thereby decreasing left atrial size.
In addition, reduction of left ventricular stiffness may have theoretically taken place but this could not be tested using the present study design.
It is suggested that EP administration within the dose range used in this study is safe for administration to healthy dogs.
Further studies are needed to explore both safety and efficacy, as well as to seek a recommended dose range of EP treatment in client-owned dogs with heart disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arita, Shinji& Arita, Noboru& Hikasa, Yoshiaki. 2020. Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study. Veterinary Medicine International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1214202
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arita, Shinji…[et al.]. Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study. Veterinary Medicine International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1214202
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arita, Shinji& Arita, Noboru& Hikasa, Yoshiaki. Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study. Veterinary Medicine International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1214202
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1214202
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر