Ruellia tuberosa L. Extract Improves Histopathology and Lowers Malondialdehyde Levels and TNF Alpha Expression in the Kidney of Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Roosdiana, Anna
Permata, Fajar Shodiq
Fitriani, Riera Indah
Umam, Khairul
Safitri, Anna
المصدر
Veterinary Medicine International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Ruellia tuberosa L.
is a therapeutic plant that is generally consumed in Indonesian traditional medicine to prevent or cure various illnesses, i.e., diabetes.
The current study was conducted to investigate the effects of hydroethanolic root extracts of Ruellia tuberosa L.
on the kidney of streptozotocin-induced diabetic Wistar rats.
In this study, male Wistar rats were divided into 5 groups: healthy rats (group 1), diabetic rats (group 2), and treated rats which received extract at dosages of 250 (group 3), 375 (group 4), and 500 (group 5) mg/kg body weight for 21 days.
Diabetes mellitus was experimentally induced by the administration of five doses of streptozotocin 20 mg/kg body weight within five consecutive days.
Significant increases in the value of TNF alpha expression and malondialdehyde (MDA) levels were observed in streptozotocin-induced diabetes rats.
Furthermore, severe histological alterations of kidney tissues occurred in the diabetic rats group.
After treatment was applied, the value of TNF alpha expression and MDA levels on the kidney decreased considerably p<0.05 in groups 3, 4, and 5.
The optimum dosage was obtained at a dose of 250 mg/kg body weight (group 3), which had 42.24% and 52.70% decrease in TNF alpha expression and MDA levels, respectively.
The histopathological profiles of the kidney also showed significant improvements in treated groups.
The most prominent recoveries were also shown in group 3.
The treatments induced repairment in the glomerular and renal tubular damages in the kidney tissues.
To conclude, these results emphasize potentially health valuable properties of hydroethanolic root extracts of R.
tuberosa L.
in rats with streptozotocin-induced diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Roosdiana, Anna& Permata, Fajar Shodiq& Fitriani, Riera Indah& Umam, Khairul& Safitri, Anna. 2020. Ruellia tuberosa L. Extract Improves Histopathology and Lowers Malondialdehyde Levels and TNF Alpha Expression in the Kidney of Streptozotocin-Induced Diabetic Rats. Veterinary Medicine International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1214238
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Roosdiana, Anna…[et al.]. Ruellia tuberosa L. Extract Improves Histopathology and Lowers Malondialdehyde Levels and TNF Alpha Expression in the Kidney of Streptozotocin-Induced Diabetic Rats. Veterinary Medicine International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1214238
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Roosdiana, Anna& Permata, Fajar Shodiq& Fitriani, Riera Indah& Umam, Khairul& Safitri, Anna. Ruellia tuberosa L. Extract Improves Histopathology and Lowers Malondialdehyde Levels and TNF Alpha Expression in the Kidney of Streptozotocin-Induced Diabetic Rats. Veterinary Medicine International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1214238
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1214238
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر