Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies
المؤلفون المشاركون
Adongo, Donatus Wewura
Kukuia, Kennedy Kwami Edem
Woode, Eric
Benneh, Charles
Boakye-Gyasi, Eric
Titiloye, Nicholas A.
Biney, Robert Peter
Mante, Priscilla Kolibea
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Pseudospondias microcarpa is used traditionally for treating various diseases.
However, although parts of the plant are extensively used in African traditional medicine, no scientific study has been reported on its toxicity.
Therefore, this study evaluated the acute and subacute toxicity studies of the ethanolic extract of P.
microcarpa in rats.
Male Sprague-Dawley rats (120–150 g) were treated orally with the extract (30, 100, 300, 1000, and 3000 mg kg−1) or distilled water (10 ml kg−1) for 2 weeks and observed daily for general appearance and signs of toxicity.
In addition, blood was collected for both biochemical and haematological assays.
Sections of tissues from liver, kidney, spleen, brain, and stomach were also used for histopathological examination.
Administration of the extract for 14 consecutive days caused no deaths, with an LD50 above 3000 mg kg−1.
Except for lymphocytes (%) that showed a significant decrease (F5,23=3.93, P=0.013), all other haematological parameters remained unaffected by the extract.
The extract at 100 mg kg−1 showed a significant decrease in the levels of triglyceride and very-low-density lipoproteins (both at P<0.05).
Weight change as well as histological evaluation of the organs indicated no toxicity.
The study demonstrates that an ethanolic extract of P.
microcarpa given orally to rats is safe.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adongo, Donatus Wewura& Mante, Priscilla Kolibea& Kukuia, Kennedy Kwami Edem& Benneh, Charles& Biney, Robert Peter& Boakye-Gyasi, Eric…[et al.]. 2018. Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies. The Scientific World Journal،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1215620
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adongo, Donatus Wewura…[et al.]. Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies. The Scientific World Journal No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1215620
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adongo, Donatus Wewura& Mante, Priscilla Kolibea& Kukuia, Kennedy Kwami Edem& Benneh, Charles& Biney, Robert Peter& Boakye-Gyasi, Eric…[et al.]. Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies. The Scientific World Journal. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1215620
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1215620
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر