Dispersive liquid liquid micro extraction spectrophotometric determination of Telmesartan and Irbesartan in pharmaceuticals samples

الملخص EN

The current work is characterized by simplicity, accuracy and high sensitivity Dispersive liquid - Liquid Micro Extraction (DLLME).

The method was developed to determine Telmesartan (TEL) and Irbesartan (IRB) in the standard and pharmaceutical composition.

Telmesartan and Irbesartan are separated prior to treatment with Eriochrom black T as a reagent and formation ion pair reaction dye.

The analytical results of DLLME method for linearity range (0.2- 6.0) mg /L for both drugs, molar orptivity were (1.67 × 105- 5.6 × 105) L/ mole.

cm, limit of detection were (0.0242and0.0238), Limit of quantification were (0.0821and0.0711), the Distribution coefficient were (238 and 226) and the preconcentration factor were (25) for Telmesartan (TEL) and Irbesartan (IRB) respectively.

The assay has been used successfully in a determination study of both in pure and pharmaceutical preparations.