Protection against paclitaxel‑induced hyperalgesia and allodynia by pomegranate seed oil, Nucleo-CMP forte®, and L‑carnitine

الملخص EN

Background: Hyperalgesia and allodynia are abnormal sensory signs which are usually seen along neuropathic pain (NP) in patients on paclitaxel (PT) chemotherapy.

Pomegranate seed oil (PSO) has been used in the traditional medicine for the different kinds of pain.

Nucleo‑CMP Forte® (NCF) is a nucleotide‑based drug and L‑carnitine (LC) is a member of natural compounds have been shown effective in diverse peripheral neuroglial disorders.

The aim of this study is to compare the anti‑hyperalgesia and anti‑allodynia activity of PSO, NCF, and LC in PT‑induced neuropathy.

Materials and Methods: Thirty adult male mice were divided equally into five groups of six mice in each group as follows: Control (C), PT, PSO (PTpso), NCF (PTn), and LC (PTc) groups.

NP was induced by the administration of PT (6 mg/kg, i.

p.

, once weekly) to the mice in all groups except C group.

PSO, NCF, and LC were administered orally once daily to mice with PT‑induced neuropathy in their corresponding groups.

Different behavior parameters were used to test the anti‑hyperalgesic and anti‑allodynic effect of PSO, NCF, and LC on days 0, 7, 14, 21, and 28 of PT administration.

Results: PSO, NCF, and LC significantly attenuated NP induced by PT from day 14 up to 28 days using the different behavioral tests for thermal hyperalgesia and allodynia.

Conclusion: PSO, NCF, and LC have significant potential anti‑nociceptive and analgesic activity against PT‑induced NP and PSO was the most efficacious than NCF and Background: Hyperalgesia and allodynia are abnormal sensory signs which are usually seen along neuropathic pain (NP) in patients on paclitaxel (PT) chemotherapy.

Pomegranate seed oil (PSO) has been used in the traditional medicine for the different kinds of pain.

Nucleo‑CMP Forte® (NCF) is a nucleotide‑based drug and L‑carnitine (LC) is a member of natural compounds have been shown effective in diverse peripheral neuroglial disorders.

The aim of this study is to compare the anti‑hyperalgesia and anti‑allodynia activity of PSO, NCF, and LC in PT‑induced neuropathy.

Materials and Methods: Thirty adult male mice were divided equally into five groups of six mice in each group as follows: Control (C), PT, PSO (PTpso), NCF (PTn), and LC (PTc) groups.

NP was induced by the administration of PT (6 mg/kg, i.

p.

, once weekly) to the mice in all groups except C group.

PSO, NCF, and LC were administered orally once daily to mice with PT‑induced neuropathy in their corresponding groups.

Different behavior parameters were used to test the anti‑hyperalgesic and anti‑allodynic effect of PSO, NCF, and LC on days 0, 7, 14, 21, and 28 of PT administration.

Results: PSO, NCF, and LC significantly attenuated NP induced by PT from day 14 up to 28 days using the different behavioral tests for thermal hyperalgesia and allodynia.

Conclusion: PSO, NCF, and LC have significant potential anti‑nociceptive and analgesic activity against PT‑induced NP and PSO was the most efficacious than NCF and LC.