In vitro antimicrobial activity of curcumin-copper complex

الملخص EN

The curcumin-copper complex was characterized by a bluish green color when dissolved in dimethylsulfoxide (DMSO), and 20000 µg ̸ ml were prepared by their dissolving in DMSO.

Through using agar well diffusion method, 100 µL of 20000 µg ̸ ml revealed the inhibitory zones (IZs) around the growth of five clinical pathogenic isolates were Staphylococcus aureus, Streptococcus mutans, Escherichia coli and Klebsiella sp.

compared with tetracycline disc (30 µg ̸ ml) besides Candida albicans was tested.

These IZs were 12, 12, 13, 16, and 40 mm respectively.

Relatedly, E.

coli, Klebsiella sp.

and C.

albicans were inhibited by 2000-10000 µg ̸ ml while no effect of 10000 µg ̸ ml on S.

aureus and S mutans.

Red blood cells had affected by 100 µL obtained from 20000 µg ̸ ml of the complex during 1 hour but 10000 µg ̸ ml resulted in very slightly effect against the cells.

Analysis of gas chromatography-mass spectrometry detected that the complex of curcumin copper contained S-methyl methanethiosulfinate; benzenediazonium, 2-hydroxy-, hydroxide, inner salt; methane, (methylsulfinyl)(methylthio)-; 2, 4-dithiapentane; silanol, dimethyl-; thiodiglycol; 2-aminoimidazole-5-propionic caid; 1, 2, 4, 5-tetrathiane; 1, 2, 4-trithiolane; sulfurous acid, diethyl ester; ethanol, 2-[2-(4-pyridyl)ethylamino]-; and methanesulfinothioic acid, S-1-propyl ester and dimethyl sulfone.

It was concluded that the tested complex has antimicrobial activity against some species of bacteria and C.

albicans as well.

The complex is needed to be studying in vivo and clinically in future work so that it may be used as a drug for treating the microbial pathogens which cause the The curcumin-copper complex was characterized by a bluish green color when dissolved in dimethylsulfoxide (DMSO), and 20000 µg ̸ ml were prepared by their dissolving in DMSO.

Through using agar well diffusion method, 100 µL of 20000 µg ̸ ml revealed the inhibitory zones (IZs) around the growth of five clinical pathogenic isolates were Staphylococcus aureus, Streptococcus mutans, Escherichia coli and Klebsiella sp.

compared with tetracycline disc (30 µg ̸ ml) besides Candida albicans was tested.

These IZs were 12, 12, 13, 16, and 40 mm respectively.

Relatedly, E.

coli, Klebsiella sp.

and C.

albicans were inhibited by 2000-10000 µg ̸ ml while no effect of 10000 µg ̸ ml on S.

aureus and S mutans.

Red blood cells had affected by 100 µL obtained from 20000 µg ̸ ml of the complex during 1 hour but 10000 µg ̸ ml resulted in very slightly effect against the cells.

Analysis of gas chromatography-mass spectrometry detected that the complex of curcumin copper contained S-methyl methanethiosulfinate; benzenediazonium, 2-hydroxy-, hydroxide, inner salt; methane, (methylsulfinyl)(methylthio)-; 2, 4-dithiapentane; silanol, dimethyl-; thiodiglycol; 2-aminoimidazole-5-propionic caid; 1, 2, 4, 5-tetrathiane; 1, 2, 4-trithiolane; sulfurous acid, diethyl ester; ethanol, 2-[2-(4-pyridyl)ethylamino]-; and methanesulfinothioic acid, S-1-propyl ester and dimethyl sulfone.

It was concluded that the tested complex has antimicrobial activity against some species of bacteria and C.

albicans as well.

The complex is needed to be studying in vivo and clinically in future work so that it may be used as a drug for treating the microbial pathogens which cause the diseases