Postdiarrheal hemolytic uremic syndrome in Egyptian children : an 11-year single-center experience
المؤلفون المشاركون
Hammad, Ayman
Zaydan, Muhammad M.
Allam, Nahlah A.
Hamdi, Nashwah
al-Rifai, Ahmad M.
Sarhan, Amr
al-Muji, Atif
Bakr, Ashraf
Id, Riham
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 31، العدد 6 (31 ديسمبر/كانون الأول 2020)، ص ص. 1376-1387، 12ص.
الناشر
تاريخ النشر
2020-12-31
دولة النشر
السعودية
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Hemolytic-uremic syndrome (HUS) is a leading cause of childhood acute kidney injury (AKI) worldwide, with its postdiarrheal (D+HUS) form being the most common.
Scarce data are available regarding D+HUS epidemiology from developing countries.
This study aims to reveal the characterization of D+ HUS in Egyptian children.
This is a retrospective study of all children with D+HUS admitted to a tertiary pediatric hospital in Egypt between 2007 and 2017.
The study included epidemiological, clinical and laboratory data; management details; and outcomes.
A cohort of 132 children aged 4months to 12 years was analyzed.
Yearly incidence peaked in 2017, and spring showed the highest peak.
All cases had a diarrheal prodrome that was bloody in 83% of the cases.
Edema and decreased urine output were the most frequent presentations (50.3% and 42.4%, respectively).
Escherichia coli was detected in 56 cases.
Dialysis was performed in 102 cases.
Eight patients died during acute illness, while five patients experienced long-term sequels.
Lactate dehydrogenase (LDH) positively correlated with serum creatinine and negatively correlated with reticulocytic count.
Univariate analysis showed that longer anuria duration, short duration between diarrheal illness and development of AKI (P = 0.001), leukocyte count above 20 × 109 cells/L (P ≤ 0.001), platelet count below 30 × 109 cells/L (P = 0.02), high LDH levels (P = 0.02) and hematocrit above 30% (P = 0.0001), need for dialysis (P = 0.03), and neurological involvement (P ≤ 0.001) were associated with unfavorable outcomes.
This is the first report with a detailed insight into the epidemiology of D+HUS in Egyptian children.
The incidence of D+HUS is increasing in our country due to increased awareness of the disease and the poor public health measures.
Anuria duration, leukocyte count, and neurological involvement are predictors of poor outcome in the current work, and LDH is introduced as a marker of disease severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Id, Riham& Bakr, Ashraf& al-Muji, Atif& Zaydan, Muhammad M.& Allam, Nahlah A.& Sarhan, Amr…[et al.]. 2020. Postdiarrheal hemolytic uremic syndrome in Egyptian children : an 11-year single-center experience. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 6, pp.1376-1387.
https://search.emarefa.net/detail/BIM-1252663
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Id, Riham…[et al.]. Postdiarrheal hemolytic uremic syndrome in Egyptian children : an 11-year single-center experience. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 6 (Nov. / Dec. 2020), pp.1376-1387.
https://search.emarefa.net/detail/BIM-1252663
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Id, Riham& Bakr, Ashraf& al-Muji, Atif& Zaydan, Muhammad M.& Allam, Nahlah A.& Sarhan, Amr…[et al.]. Postdiarrheal hemolytic uremic syndrome in Egyptian children : an 11-year single-center experience. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 6, pp.1376-1387.
https://search.emarefa.net/detail/BIM-1252663
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1385-1387
رقم السجل
BIM-1252663
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر