Treatment effect of licorice and frankincense eldakr from pneumonia induced by bacterial liposaccharides in rats

الملخص EN

Acute lung injury is a serious illness with a high death rate, resulting in more significant diseases.

Thus, this study evaluated the licorice extract for flavonoid compounds and frankincense extract for the essential oil to treat pneumonia in experimental animals.

The results found that the major flavonoid compounds in licorice extract were Rutin, Quercetin-3-O-glucoside, Vitexin, and Apigenin-7-O-β-glucoside, whilst, Narengin, Quercetin, Luteolin-7-O-β-glucoside, and Epicatechin were found in medium amounts.

Furthermore, it could be noticed the licorice extract contained antioxidant activity which scavenging free radicals.

Meanwhile, Frankincense oil could be identified and the major compounds were µ- Pinene, Limonene, µ-Campholenal, and β-Fenchene whilst, P-Cymene, µ- Thujene, Octanal, and Sabinene were found in medium amounts.

The biological experiment observed that the male rats were divided into five groups; the first group was considered a negative control.

The rest were injected with 50 mg/kg of lipopolysaccharide (LPS) to cause pneumonia, after that, re-divided the rat groups.

The second group considered as a positive control group, while the 3 and 4 groups were taken orally/day separately 200 ppm /kg BW rat from each licorice and frankincense, and group 5 was taken orally/ day 200ppm from both licorice and frankincense aqueous extract was for four weeks during the experimental period.

The results found that group 5 which was taken orally/ day 200ppm from both licorice and frankincense extract give the best results to improve the complete blood picture, inhibition of inflammation and oxidative stress, followed by the groups were taken orally/day separately 200 ppm /kg BW rat /day from each licorice and frankincense, respectively.

The result could be recommended to use the licorice and frankincense extract as a new curative agent for treating the pneumonia of rats induced by bacterial liposaccharides.