Bone marrow transplantation program pediatric oncology experience at king hussein medical center

الملخص EN

Objective: To evaluate the pediatric bone marrow transplantation program at King Hussein Medical Center, between June 1997 to December 2002.

Methods: Fourteen children were transplanted with a median age of 9.5 years (range: 4-13 years), with the following diseases; Severe aplastic anemia (5), acute lymphoblastic leukemia (2), acute myeloid leukemia (4), chronic granulocytic leukemia (1), hyper-immunoglobulin M syndrome (1) and Fanconi’s anemia (1).

All children and their donors were prepared before bone marrow transplantation according to our protocol.

Results: The patients engrafted at a median day +15 post transplant (range: 11-25 days).

The mortality rate due to transplant-related toxicity was 14.3 % at +100 days and the overall disease-free survival was 78.6 % at a median follow-up period of 16.5 months post transplant (range: 1-66 months).

Conclusion: The results of the pediatric bone marrow transplantation program over the last few years were comparable to those reported from other centers in terms of mortality and morbidity.

All these make it worthy to move on with the program.