Effects of folic acid consumption on newborn defects and miscarriage, and content uniformity analysis of three different brands of folic acid tablets dosage forms
العناوين الأخرى
تأثير تناول الحمض الفوليكي على التشوهات الجنينية و حالات الإجهاض و تحليل وحدة مكونات الجرعة لثلاث علامات تجارية للحمض الفوليكي على شكل أقراص
المؤلفون المشاركون
Muhammad, Adil Blqasm
Ali, Azzah Manbi
Majid, Samiyah al-Sawi
المصدر
Al-Mukhtar Journal of Sciences
العدد
المجلد 34، العدد 4 (31 ديسمبر/كانون الأول 2019)، ص ص. 256-264، 9ص.
الناشر
تاريخ النشر
2019-12-31
دولة النشر
ليبيا
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
There is a recent rise in the number of birth defects.
This could be related to folic acid deficiency.
Folic acid, as an antioxidant, is an important factor in preventing birth defects during embryonic development.
This study, via content uniformity measurements and medical history, aimed to investigate the role of folic acid before and during pregnancy and to measure the content uniformity of different brands of folic acid tablets.
The statistical study aimed to determine the rela-tionship between folic acid consumption, miscarriage, and anomalies in newborn babies.
The study studied a sample of 300 women based on their medical records.
There was no significant effect (p-value = 0.143) of folic acid consumption on the frequency of anomalies.
On the other hand, there was a high significant relation (p-value = 0.003) between folic acid consumption and miscarriage.
The correlation, principally with miscarriage, coincides with previous studies and highlights the importance of folic acid supplementation before and during gestation.
Content uniformity meas-urements were made on three famous folic acid brands (Folic Acid-Nile, Folicum-Julphar and Wockhardt-UK) available at local pharmacies.
Measurements on the three folic acid brands were conducted in compliance with the British Pharmacopoeia (BP) (2010) test for content uniformity.
Ten tablets from each brand were tested using the UV spectrophotometric method.
The results showed that only the first brand name passed the content uniformity test, while the other two brands did not comply with the standards.
This result highlights the problem of under-dosing in commer-cially available folic acid dosage forms, and identifies the need for taking action towards the im-plementation of quality control on all medical drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Adil Blqasm& Ali, Azzah Manbi& Majid, Samiyah al-Sawi. 2019. Effects of folic acid consumption on newborn defects and miscarriage, and content uniformity analysis of three different brands of folic acid tablets dosage forms. Al-Mukhtar Journal of Sciences،Vol. 34, no. 4, pp.256-264.
https://search.emarefa.net/detail/BIM-1325496
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Adil Blqasm…[et al.]. Effects of folic acid consumption on newborn defects and miscarriage, and content uniformity analysis of three different brands of folic acid tablets dosage forms. Al-Mukhtar Journal of Sciences Vol. 34, no. 4 (2019), pp.256-264.
https://search.emarefa.net/detail/BIM-1325496
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Adil Blqasm& Ali, Azzah Manbi& Majid, Samiyah al-Sawi. Effects of folic acid consumption on newborn defects and miscarriage, and content uniformity analysis of three different brands of folic acid tablets dosage forms. Al-Mukhtar Journal of Sciences. 2019. Vol. 34, no. 4, pp.256-264.
https://search.emarefa.net/detail/BIM-1325496
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 262-263
رقم السجل
BIM-1325496
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر