Some pharmacodynamic studies on buparvaquone in male rats

الملخص EN

The present study was conducted to evaluate some effects of Buparvaquone on male fertility, as well as it’s effects on the liver and kidney functions tests, some hematological parameters and histopathological changes.

therefore,75 mature male rats were used and equally divided into 5 groups; group1, rats were injected with propylene glycol 2.5 ml/kg b.wt i.m and kept as a control group ; group2 rats were treated with buparvaquone at a dose of 2.5 mg/kg b.wt i.m given as a single dose ; group3 rats were treated with buparvaquone at a dose of 2.5 mg/kg b.wt i.m given twice with 2 weeks apart ; group4 rats were treated with buparvaquone at a dose of 5 mg/kg b.wt i.m given as a single dose.

Group5 rats were treated with buparvaquone at a dose of 5 mg/kg b.wt i.m given twice with 2 weeks interval.

five rats from each treated and control groups were killed after 2, 4, 8 weeks from the beginning of drug administration.

the obtained results showed that administration of buparvaquone at a dose of 5 mg/kg b.wt.

i.m either injected once or twice induced a reduction in sperm cell count and packed cell volume at 4th and 8th week of the experiment.

also there was an elevation in Hb at 4th week and creatinine values at 8th week in the same groups.

there was a significant increase in alkaline phosphate and creatinine values in group treated with buparvaquone at a dose of 5 mg/kg b.wt.

i.m injected twice at 4th week.

it could be concluded that buparvaquone is a safe drug when used with recommended dose.

however; it induced some adverse effects in high repeated dose.