Anti-oxidative role of lipoic acid against lead-induced hepatic toxicity in Japanese quails
المؤلفون المشاركون
Abu Ismail, Muhammad I.
Lubdah, Muhammad
Mandur, Abd al-Wahhab A.
Taha, Nabil
المصدر
Alexandria Journal of Veterinary Sciences
العدد
المجلد 54، العدد 2 (31 يوليو/تموز 2017)، ص ص. 13-18، 6ص.
الناشر
جامعة الإسكندرية كلية الطب البيطري
تاريخ النشر
2017-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Quails are exposed to deleterious doses of lead from different sources which decrease the bird performance, and growth with economic loses.
This work aimed to explore the antioxidative effect of alpha lipoic acid to counteract the adverse effects of lead in Japanese quails.
Forty Japanese quails with both sex were grouped into control, lead acetate (100 ppm in drinking water), alpha lipoic acid (1 g/kg diet), and the final group which received both lipoic acid and lead acetate of the same doses.
Lead acetate significantly increased the liver enzymatic biomarkers (ALT, AST, and ALP), and bilirubin levels with decline in the serum total protein and albumin concentrations.
Also, lead, copper concentrations in liver tissue were significantly increased with decreased hepatic iron level and serum calcium and phosphorus levels following lead acetate administration.
Moreover, lead significantly increased hepatic malondialdehyde level with attenuation of antioxidant enzymes; GPX, GST, CAT, and SOD activities and non- enzymatic antioxidant; GSH concentration.
Co-administration of alpha-lipoic acid together with lead acetate significantly improved the liver functions, increased the antioxidant activities, and corrected the serum and hepatic major and trace element concentrations without any effect on hepatic lead level.
Our results suggested that alpha lipoic acid can counteract the deleterious effects of lead in quails through attenuation of oxidative stress and enhancement of antioxidative capacity in liver tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abu Ismail, Muhammad I.& Taha, Nabil& Mandur, Abd al-Wahhab A.& Lubdah, Muhammad& Hashim, Amal E.. 2017. Anti-oxidative role of lipoic acid against lead-induced hepatic toxicity in Japanese quails. Alexandria Journal of Veterinary Sciences،Vol. 54, no. 2, pp.13-18.
https://search.emarefa.net/detail/BIM-1331548
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hashim, Amal E.…[et al.]. Anti-oxidative role of lipoic acid against lead-induced hepatic toxicity in Japanese quails. Alexandria Journal of Veterinary Sciences Vol. 54, no. 2 (Jul. 2017), pp.13-18.
https://search.emarefa.net/detail/BIM-1331548
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abu Ismail, Muhammad I.& Taha, Nabil& Mandur, Abd al-Wahhab A.& Lubdah, Muhammad& Hashim, Amal E.. Anti-oxidative role of lipoic acid against lead-induced hepatic toxicity in Japanese quails. Alexandria Journal of Veterinary Sciences. 2017. Vol. 54, no. 2, pp.13-18.
https://search.emarefa.net/detail/BIM-1331548
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 17-18
رقم السجل
BIM-1331548
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر