Antibodies to erythropoietin are associated with erythropoietin resistance in hemodialysis patients in Kwazulu-Natal (South Africa)
المؤلفون المشاركون
Krishna, Suresh Babu Naidu
Benjamin, Shirin
Adam, Jamilah
Assounga, Alain G.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 31، العدد 5 (31 أكتوبر/تشرين الأول 2020)، ص ص. 917-926، 10ص.
الناشر
تاريخ النشر
2020-10-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Recombinant human erythropoietin (rHuEPO) is a glycoprotein and biological equivalent to the endogenous compound administered to treat anemia of end-stage renal disease patients.
Resistance to rHuEPO has been reported, whereby patients require higher and higher doses of rHuEPO to maintain an adequate hemoglobin level.
In this study, assessment of native and administered erythropoietin (EPO), antibody and hemoglobin levels was carried out on a sample of patients with renal failure on hemodialysis (HD).
This is a randomized controlled trial where consecutive subjects attending HD units at Addington Hospital and King Edward Hospital, Durban (South Africa) were included until the target number was reached.
Forty patients with renal failure on HD and receiving recombinant EPO Beta (Recormon) for treatment of anemia via the subcutaneous route in weekly doses of 2000 IU, 4000 IU, 6000 IU, 8000 IU, 12,000 IU, or 18,000 IU according to the severity of the anemia were included after obtaining informed consent.
Also included in the study were 10 HD patients not on rHuEPO therapy and 10 healthy individuals from the Durban University of Technology, recruited as described above to form the control group.
ELISA was used to measure serum levels of EPO as well as antibodies to EPO.
Results were analyzed by descriptive, inferential methods and by logistic regression analysis using IBM SPSS Statistics for Windows version 22.0.
Antibodies to EPO were found in almost all patients who were receiving EPO.
The highest levels of antibody to EPO were found to be associated with patients receiving the highest weekly dose of EPO (18,000 IU).
Logistic regression analysis also revealed that serum levels of EPO, gender or age were not associated with any significant variation of serum antibody level.
High levels of serum antibodies to EPO are a risk factor for EPO resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Benjamin, Shirin& Adam, Jamilah& Krishna, Suresh Babu Naidu& Assounga, Alain G.. 2020. Antibodies to erythropoietin are associated with erythropoietin resistance in hemodialysis patients in Kwazulu-Natal (South Africa). Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 5, pp.917-926.
https://search.emarefa.net/detail/BIM-1331670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Assounga, Alain G.…[et al.]. Antibodies to erythropoietin are associated with erythropoietin resistance in hemodialysis patients in Kwazulu-Natal (South Africa). Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 5 (Sep. / Oct. 2020), pp.917-926.
https://search.emarefa.net/detail/BIM-1331670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benjamin, Shirin& Adam, Jamilah& Krishna, Suresh Babu Naidu& Assounga, Alain G.. Antibodies to erythropoietin are associated with erythropoietin resistance in hemodialysis patients in Kwazulu-Natal (South Africa). Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 5, pp.917-926.
https://search.emarefa.net/detail/BIM-1331670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 924-926
رقم السجل
BIM-1331670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر