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Aspirin-triggered Lipoxin protects lipopolysaccharide-induced acute kidney injury via the TLR4MyD88NF-κB pathway
المؤلفون المشاركون
Peng, Hongjun
Gao, Chunlin
Fan, Zhongmin
Xia, Zhengkun
Zhang, Pei
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 31، العدد 5 (31 أكتوبر/تشرين الأول 2020)، ص ص. 937-945، 9ص.
الناشر
تاريخ النشر
2020-10-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The protective effect of aspirin-triggered lipoxin (ATL) on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) and its possible mechanisms were explored.
To induce acute renal injury, mice were treated with LPS.
Concentration of serum creatinine (SCr) and blood urea nitrogen (BUN) was detected, and inflammatory cytokines and AKI biomarkers were determined by ELISA.
The relative protein expression levels of TLR4/myeloid differentiation factor 88 (MyD88)/NF-κB signal pathway was assessed by Western blot.
Mice subjected to LPS (4 mg/kg) treatment exhibited AKI demonstrated by markedly increased SCr and BUN levels compared with controls (P <0.01).
Treatment with ATL decreased SCr and BUN levels after LPS injection (P <0.01).
AKI biomarkers, such as urine NGAL, KIM-1, netrin-1, and L-FABP levels, increased by LPS and were inhibited by ATL (P <0.01).
ATL also reduced LPS-induced secretion of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1β, IL-6, and IL-8 (P <0.01).
Furthermore, mice pretreated with ATL before exposure to LPS showed a reduction in TLR, MyD88, and p65 phosphorylation (P <0.01), which are the key factors of the TLR/MyD88/NF-κB signaling pathway.
These results indicated that ATL had protective effects on renal function and showed amelioration of LPS-induced kidney injury.
The mechanisms underlying the protective effects of ATL can be considered are related to attenuation of the TLR4/MyD88/NF-κB signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Pei& Peng, Hongjun& Gao, Chunlin& Fan, Zhongmin& Xia, Zhengkun. 2020. Aspirin-triggered Lipoxin protects lipopolysaccharide-induced acute kidney injury via the TLR4MyD88NF-κB pathway. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 5, pp.937-945.
https://search.emarefa.net/detail/BIM-1331672
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Pei…[et al.]. Aspirin-triggered Lipoxin protects lipopolysaccharide-induced acute kidney injury via the TLR4MyD88NF-κB pathway. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 5 (Sep. / Oct. 2020), pp.937-945.
https://search.emarefa.net/detail/BIM-1331672
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Pei& Peng, Hongjun& Gao, Chunlin& Fan, Zhongmin& Xia, Zhengkun. Aspirin-triggered Lipoxin protects lipopolysaccharide-induced acute kidney injury via the TLR4MyD88NF-κB pathway. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 5, pp.937-945.
https://search.emarefa.net/detail/BIM-1331672
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 944-945
رقم السجل
BIM-1331672
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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