Colistin-induced nephrotoxicity in a tertiary teaching hospital
المؤلفون المشاركون
Abd al-Karim, Dalal A.
al-Zuwayid, Umar A.
al-Ammari, Maha
al-Halwan, Shadha
al-Maklafi, Nada
Thomas, Abin
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 31، العدد 5 (31 أكتوبر/تشرين الأول 2020)، ص ص. 1057-1061، 5ص.
الناشر
تاريخ النشر
2020-10-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Colistin-induced nephrotoxicity is a well-known major adverse event, which may occur within seven days [early acute kidney injury (AKI)] with a high mortality rate of 70% or after seven days (late AKI).
The main objective of this retrospective study is to assess the severity and associated risk factors for the development of colistin-related nephrotoxicity.
An observational retrospective cohort study was conducted over 12 months (January–December 2017).
All patients with a baseline normal renal function, who received intravenous colistin for >72 h, were included.
Nephrotoxicity was defined using the RIFLE criteria (Risk, Injury, Failure, Loss, and End-stage renal disease).
The demographic and clinical variables were retrieved from the hospital's electronic medical record system and compiled in an electronic database.
All the statistical analysis was carried out by SAS JMP from SAS Institute Inc., Cary, NC.
Seventy patients met the inclusion criteria.
Colistin-induced nephrotoxicity occurred in 45.71% of the patients, of whom 40.6% were at Risk, 21.9% at Injury, and 37.5% at Failure according to RIFLE criteria.
In patients who developed AKI, the average total colistin dose received before AKI was 4.4 mg/kg/day.
More than half of the AKI group (53.13%) received an inappropriate total dose of colistin.
Age, 65 years and older, was significantly associated with a high risk of nephrotoxicity (P <0.05), which developed within 6.8 ± 0.44 days from receiving a colistin dose.
Clinical pharmacy services were consulted in 28.13% of the cases, and the dose was adjusted in 37.5% of the patients.
Colistin nephrotoxicity is common and is associated more with older age group and inappropriate dosing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Karim, Dalal A.& al-Zuwayid, Umar A.& al-Ammari, Maha& al-Halwan, Shadha& al-Maklafi, Nada& Thomas, Abin. 2020. Colistin-induced nephrotoxicity in a tertiary teaching hospital. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 5, pp.1057-1061.
https://search.emarefa.net/detail/BIM-1332840
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Karim, Dalal A.…[et al.]. Colistin-induced nephrotoxicity in a tertiary teaching hospital. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 5 (Sep. / Oct. 2020), pp.1057-1061.
https://search.emarefa.net/detail/BIM-1332840
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Karim, Dalal A.& al-Zuwayid, Umar A.& al-Ammari, Maha& al-Halwan, Shadha& al-Maklafi, Nada& Thomas, Abin. Colistin-induced nephrotoxicity in a tertiary teaching hospital. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 5, pp.1057-1061.
https://search.emarefa.net/detail/BIM-1332840
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1061
رقم السجل
BIM-1332840
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر