Efficacy of n-acetylcysteine and hydrated sodium calcium aluminosilicate to reduce the effects of aflatoxin b1intoxication in broiler chickens

الملخص EN

This research was planned to determine the efficacy of n-acetylcysteine (NAC) and/or hydrated sodium calcium aluminosilicate (HSCAS) to combat aflatoxin B1 (AFB1) toxic effects in broiler chickens.

a total of 720, day-old broiler chicks were distributed equally to eight experimental treatments with three 30 bird replicates each.

the first treatment was fed basal diet and used as control.

the other treatments (from 2 to 8 ) were fed the same basal diet and supplied with NAC alone (100 mg/kg diet), HSCAS alone (5 g/kg diet), NAC (100 mg/kg diet) plus HSCAS alone (5 g/kg diet), AFB1 alone in the diet (1 mg/kg of diet) for 42 d, AFB1 plus NAC (100 mg/kg diet) , AFB1 plus HSCAS (5 g/kg diet) and AFB1 plus NAC (100 mg/kg diet) plus HSCAS alone (5 g/kg diet, respectively).

aflatoxin caused to a significant reduces in the activity of serum and hepatic catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH).

however, serum malondialdehyde (MDA), liver and kidney function levels have increased.

After the chicks diets were exposed to aflatoxin B1 pollutions, pancreatic enzyme activity showed a significant enhance in serum lipase and amylase activity.

moreover, aflatoxin B1 group had a reduce in levels of serum albumin, total protein, beta globulin, alpha globulin and gamma globulin together with A/G ratio.

N-acetylcysteine and/or HSCAS administration resulted in decreased levels of malondialdehyde (MAD) and increased levels of CAT, GSH and SOD compared with the contaminated group.

Therefore, due to the protective effects of N-acetylcysteine and/or HSCAS, the concentrations of AST, ALT, serum lipase and amylase are significantly decreased.

broilers fed AFB1 plus NAC, HSCAS and NAC plus HSCAS were shown to be partially protected against adverse effects on BWG (68.38, 61.24 and 84.17 %), daily feed intake (76.92, 72.87and 86.96 %), feed conversion ratio (82.91, 73.64 and 99.65 %), serum total protein concentration, liver and kidney function, hepatic glutathione-Stransferase, and reduced glutathione liver concentration.

our findings suggest that NAC provided protection in broiler chickens against negative performance effects and biochemical changes caused by AFB1.

also assessed were the effects of NAC on chick performance alone.

adding NAC to diet (100 mg / kg diet) did not adversely affect feed intake, feed conversion ratio, or serum chemistry and did not result in structural changes in the liver or kidney.