Study the effect of doum-palm and fennel as anti-hyperlipidemic agents in experimental rats

الملخص EN

Several epidemiological and trial clinical studies have reported that dyslipidemia is a major contributor to atherosclerotic cardiovascular disease (ASCVD), So that; the present study was carried out to investigate the effect of Doum-palm and Fennel as anti-hyperlipidemic agents in experimental rats.

Thirty-six male albino rats weighing 130 ± 20 g were used in this study and divided into two main groups, the first main group ( 6 rats ) kept as a negative control group (v -) received a basal diet throughout the experiment period ( seven weeks ), while the second main group (30 rats) fed on a high-fat diet for three weeks to induce hyperlipidemia .

After that the rats in the second main group (30) were divided into five subgroups, the first was the (v +) control group, the second and third given a basal diet supplemented with doum-palm (5%) and (10 %) , respectively .

the four and five given a basal diet supplemented with fennel (5%) and (10%) , respectively for four weeks.

The chemical composition for both plants was done.

The results showed that the amount of total phenolics in doum palm and fennel were (0.270 and 0.357 % respectively).

While , the amount of total flavonoids were (23.015 and 34.227 mg/100g respectively).

At the end of the experiment, biological data were calculated; blood samples were taken to biochemical analysis.

In addition, a histopathological examination for the liver was done.

The results revealed that high fat diet in the (v +) control group increased body weight gain %, relative organ weight, serum lipid profile, Malondialdehyde (MDA), liver enzymes and serum glucose, decreased in serum HDL-C, serum Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx).

All treated groups with two plants showed improvement previously parameters compared with the positive control group.

In conclusion, the consumption of doum-palm and fennel (5 and 10%) could be used for improving lipid profile, liver function and protect from the risk factor of hyperlipidemia in experimental rats