Effect of lactobacillus acidophilus on trichinella spiralis muscle larvae in experimentally infected mice compared to its effect when combined with albendazole and-or nitazoxanide

الملخص EN

This study evaluated the therapeutic and synergistic effects of lactobacillus acidophilus (l.

acidophilus), a probiotic, and nitazoxanide (NTZ) as compared to the used, albendazole (ABZ), as single therapy and in combination.

ABZ / L.

acidophilus-treated group showed the highest reduction of encysted larvae (92.5%) as compared to control and to ABZ-treated mice.

also, NTZ treatment showed a significant decrease in larval counts compared to control (40.95%), which was comparable to that produced by L.

acidophilus single therapy.

but, combined NTZ with L.

acidophilus caused a significantly higher reduction of larvae (56.62%) highlighted SYN-ergistic abilities of both.

histopathological examination showed marked decrease in larval counts and inflammatory reactions in ABZ / L.

acidophilus-treated group.

combined L.

acidophil-us with other therapeutics caused increased eosinophilia degeneration and larval replacement.