Curcumin a potential antagonist against paracetamol induced nephrotoxicity in rats
المؤلفون المشاركون
Taha, Nabil M.
Mandur, Abd al-Wahhab A.
Hashim, Amal E.
Ibrahim, Manal R.
Libdah, Muhammad A.
المصدر
Alexandria Journal of Veterinary Sciences
العدد
المجلد 62، العدد 2 (31 يوليو/تموز 2019)، ص ص. 37-44، 8ص.
الناشر
جامعة الإسكندرية كلية الطب البيطري
تاريخ النشر
2019-07-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Paracetamol can cause a life threating renal damage and there is no specific treatment for it.
Therefore, the current study aims to investigate the nepheroprotective effect of curcumin against paracetamol nephrotoxicity in rats through determination of kidney function parameters, minerals concentration, kidney lipid peroxidation and antioxidants.
To achieve this aim, seventy adult male albino rats were divided into equal seven groups as following, Group I served as control,Group II (corn oil treated group), Group III (curcumin200 mg/kg b.wt/orally), Group IV (Curcumin 400 mg/kg b.wt/orally), Group V served as positive control (Paracetamol 500 mg/kg b.wt/orally), Group VI (Curcumin 200 mg/kg b.wt and paracetamol 500 mg/kg b.wt/orally), and Group VII (Curcumin 400 mg/kg b.w and paracetamol 500 mg/kg b.w/orally).
At the end of experiment (after 30 days), blood and tissue samples were collected for biochemical, and histopathological analysis.
Renal toxicity and oxidative stress were observed in untreated paracetamol-intoxicated rats as there was significant increase in urea, creatinine, uric acid and sodium concentration with significant decrease in serum concentration of potassium, calcium, and phosphorus, moreover malondialdehyde (MDA) was significantly increased while, reduced glutathione (GSH) level and catalase (CAT) activity were decreased compared to control, in addition to congestion of the renal glomerular tuft and marked renal tubular degeneration in histopathological examination .
Administration of curcumin attenuated the detrimental effects of paracetamol in a dose-dependent manner via decrease of elevated kidney function biomarkers and correction of minerals concentration levels, decrease MDA level and increase in GSH level and CAT activity as well as induced amelioration in the histopathological damage.
The obtained results of this study revealed that curcumin showed protective effects against paracetamol-induced renal toxicity through its powerful antioxidant properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Manal R.& Taha, Nabil M.& Mandur, Abd al-Wahhab A.& Libdah, Muhammad A.& Hashim, Amal E.. 2019. Curcumin a potential antagonist against paracetamol induced nephrotoxicity in rats. Alexandria Journal of Veterinary Sciences،Vol. 62, no. 2, pp.37-44.
https://search.emarefa.net/detail/BIM-1341440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Manal R.…[et al.]. Curcumin a potential antagonist against paracetamol induced nephrotoxicity in rats. Alexandria Journal of Veterinary Sciences Vol. 62, no. 2 (Jul. 2019), pp.37-44.
https://search.emarefa.net/detail/BIM-1341440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Manal R.& Taha, Nabil M.& Mandur, Abd al-Wahhab A.& Libdah, Muhammad A.& Hashim, Amal E.. Curcumin a potential antagonist against paracetamol induced nephrotoxicity in rats. Alexandria Journal of Veterinary Sciences. 2019. Vol. 62, no. 2, pp.37-44.
https://search.emarefa.net/detail/BIM-1341440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 42-44
رقم السجل
BIM-1341440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر